{"title":"Dietary proanthocyanidins for improving gut immune health","authors":"Chang Liu, Bradley W Bolling","doi":"10.1016/j.cofs.2024.101133","DOIUrl":null,"url":null,"abstract":"<div><p>Proanthocyanidins (PACs) are bioactive polyphenols with varying distribution in plants. Most dietary PACs are highly polymerized with limited absorption in the gastrointestinal tract. However, emerging evidence highlights that incorporating PACs into the diet enhances immune function through gut-mediated mechanisms. These include modulating gut microbiota, inhibiting microbes, dampening immunocytes and inflammatory pathways, improving gut barrier function, and enhancing antioxidant activity. Nevertheless, further research is needed to determine the structure–function relationships of PACs with these potential immune benefits. Additional human intervention studies are needed to clarify the dose–response and mechanisms responsible for improving health. Addressing these gaps will aid in developing specific dietary recommendations for PACs to enhance gut immune health and reduce chronic disease risk.</p></div>","PeriodicalId":54291,"journal":{"name":"Current Opinion in Food Science","volume":"56 ","pages":"Article 101133"},"PeriodicalIF":8.9000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214799324000110/pdfft?md5=303cb110a09bfae024566b8d3ee3e649&pid=1-s2.0-S2214799324000110-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Food Science","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214799324000110","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Proanthocyanidins (PACs) are bioactive polyphenols with varying distribution in plants. Most dietary PACs are highly polymerized with limited absorption in the gastrointestinal tract. However, emerging evidence highlights that incorporating PACs into the diet enhances immune function through gut-mediated mechanisms. These include modulating gut microbiota, inhibiting microbes, dampening immunocytes and inflammatory pathways, improving gut barrier function, and enhancing antioxidant activity. Nevertheless, further research is needed to determine the structure–function relationships of PACs with these potential immune benefits. Additional human intervention studies are needed to clarify the dose–response and mechanisms responsible for improving health. Addressing these gaps will aid in developing specific dietary recommendations for PACs to enhance gut immune health and reduce chronic disease risk.
期刊介绍：
Current Opinion in Food Science specifically provides expert views on current advances in food science in a clear and readable format. It also evaluates the most noteworthy papers from original publications, annotated by experts.
Key Features:
Expert Views on Current Advances: Clear and readable insights from experts in the field regarding current advances in food science.
Evaluation of Noteworthy Papers: Annotated evaluations of the most interesting papers from the extensive array of original publications.
Themed Sections: The subject of food science is divided into themed sections, each reviewed once a year.
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