P176: Efficacy of Melatonin in Delayed Sleep Phase Disorder: An Umbrella Review

IF 4.6 2区医学 Q1 GERIATRICS & GERONTOLOGY

International psychogeriatrics Pub Date : 2024-02-02 DOI:10.1017/s1041610223004283

CT Tang, SM Tan

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引用次数: 0

Abstract

Objective:The most recent treatment guidelines on delayed sleep phase disorder recommend the use of melatonin. However, these guidelines are in need of an update. Numerous systematic reviews and meta-analyses have since been conducted. This research aims to summarize all systematic reviews and meta-analyses investigating the efficacy of melatonin in delayed sleep phase disorder.Methods:We performed a literature search using Pubmed, Embase, Cochrane Database of Systematic Reviews and Google. Characteristics and findings of all eligible systematic reviews and meta-analyses were summarised.Results:Five reviews, which included trials up to 2014, were obtained. The timing of melatonin administration and outcomes of interest varied considerably amongst the trials. All of the reviews found improvement in sleep-onset latency, while two reviews noted advancement in melatonin onset time.Conclusions:There is a need for more updated evidence exploring the use of melatonin in delayed sleep phase disorder. Future studies should also specify if they are evaluating the hypnotic and/or chronobiotic effects of melatonin and consider these in their design.

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P176：褪黑素对延迟睡眠障碍的疗效：综述

目标：关于睡眠时相延迟症的最新治疗指南建议使用褪黑素。然而，这些指南需要更新。自此以后，进行了大量的系统综述和荟萃分析。本研究旨在总结所有研究褪黑素对延迟睡眠障碍疗效的系统综述和荟萃分析。方法：我们使用 Pubmed、Embase、Cochrane 系统综述数据库和 Google 进行了文献检索。结果：共获得5篇综述，其中包括截至2014年的试验。不同试验的褪黑素给药时间和相关结果差异很大。所有综述均发现睡眠起始潜伏期有所改善，而两篇综述指出褪黑激素起始时间有所提前。结论：需要更多最新证据来探讨褪黑激素在延迟睡眠期障碍中的应用。未来的研究还应明确说明他们是否在评估褪黑素的催眠和/或慢性生物效应，并在设计中考虑这些因素。

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来源期刊

International psychogeriatrics 医学-精神病学

CiteScore

9.10

自引率

8.60%

发文量

217

审稿时长

3-6 weeks

期刊介绍： A highly respected, multidisciplinary journal, International Psychogeriatrics publishes high quality original research papers in the field of psychogeriatrics. The journal aims to be the leading peer reviewed journal dealing with all aspects of the mental health of older people throughout the world. Circulated to over 1,000 members of the International Psychogeriatric Association, International Psychogeriatrics also features important editorials, provocative debates, literature reviews, book reviews and letters to the editor.