The use of a systems approach to increase NAD+ in human participants

IF 5.4 Q1 GERIATRICS & GERONTOLOGY
John D. Henderson, Sophia N. Z. Quigley, Shruti S. Chachra, Nichola Conlon, Dianne Ford
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引用次数: 0

Abstract

Reversal or mitigation against an age-related decline in NAD+ has likely benefits, and this premise has driven academic and commercial endeavour to develop dietary supplements that achieve this outcome. We used a systems-based approach to improve on current supplements by targeting multiple points in the NAD+ salvage pathway. In a double-blind, randomised, crossover trial, the supplement – Nuchido TIME+® (NT) - increased NAD+ concentration in whole blood. This was associated with an increase in SIRT1 and an increase in nicotinamide phosphoribosyltransferase (NAMPT) in peripheral blood mononucleocytes, lower concentrations of pro-inflammatory cytokines in plasma, including a reduction in interleukin 2 (IL2), a reduction in glycated serum protein and a shift in the glycosylation profile of immunoglobulin G (IgG) toward a younger biological age, all of which are likely to promote a healthier ageing trajectory.

Abstract Image

采用系统方法增加人类参与者体内的 NAD+
逆转或缓解与年龄有关的 NAD+ 减少可能会带来益处,这一前提促使学术界和商业界努力开发可实现这一结果的膳食补充剂。我们采用了一种基于系统的方法,通过针对 NAD+ 挽救途径中的多个点来改进目前的补充剂。在一项双盲、随机、交叉试验中,补充剂 Nuchido TIME+® (NT) 提高了全血中 NAD+ 的浓度。这与外周血单核细胞中 SIRT1 的增加和烟酰胺磷酸核糖转移酶 (NAMPT) 的增加、血浆中促炎细胞因子浓度的降低(包括白细胞介素 2 (IL2) 的减少)、糖化血清蛋白的减少以及免疫球蛋白 G (IgG) 糖基化谱向更年轻生物年龄的转变有关,所有这些都可能促进更健康的老龄化轨迹。
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来源期刊
NPJ Aging and Mechanisms of Disease
NPJ Aging and Mechanisms of Disease Medicine-Geriatrics and Gerontology
自引率
0.00%
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0
审稿时长
8 weeks
期刊介绍: npj Aging and Mechanisms of Disease is an online open access journal that provides a forum for the world’s most important research in the fields of aging and aging-related disease. The journal publishes papers from all relevant disciplines, encouraging those that shed light on the mechanisms behind aging and the associated diseases. The journal’s scope includes, but is not restricted to, the following areas (not listed in order of preference): • cellular and molecular mechanisms of aging and aging-related diseases • interventions to affect the process of aging and longevity • homeostatic regulation and aging • age-associated complications • translational research into prevention and treatment of aging-related diseases • mechanistic bases for epidemiological aspects of aging-related disease.
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