Down-expression of miR-494-3p in senescent osteocyte-derived exosomes inhibits osteogenesis and accelerates age-related bone loss via PTEN/PI3K/AKT pathway.

IF 4.7 2区医学 Q2 CELL & TISSUE ENGINEERING

Bone & Joint Research Pub Date : 2024-02-01 DOI:10.1302/2046-3758.132.bjr-2023-0146.r2

Chen Yao, Jie Sun, Wanxin Luo, Hao Chen, Tianhao Chen, Cao Chen, Bo Zhang, Yafeng Zhang

引用次数: 0

Abstract

To investigate the effects of senescent osteocytes on bone homeostasis in the progress of age-related osteoporosis and explore the underlying mechanism.

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衰老骨细胞衍生外泌体中 miR-494-3p 的下表达会通过 PTEN/PI3K/AKT 通路抑制成骨过程并加速与年龄相关的骨质流失。

研究衰老骨细胞在老年性骨质疏松症进展过程中对骨稳态的影响，并探索其潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bone & Joint Research CELL & TISSUE ENGINEERING-ORTHOPEDICS

CiteScore

7.40

自引率

23.90%

发文量

156

审稿时长

12 weeks

期刊介绍： The gold open access journal for the musculoskeletal sciences. Included in PubMed and available in PubMed Central.