Identification of cuproptosis-related lncRNAs signature for predicting the prognosis in patients with kidney renal clear cell carcinoma

IF 3.5 Q3 Biochemistry, Genetics and Molecular Biology

Journal of Genetic Engineering and Biotechnology Pub Date : 2024-01-30 DOI:10.1016/j.jgeb.2023.100338

Ya He , Hongxia Zhang , Jingang Li , Hui Zhou , Fei Wang , Guangliang Zhang , Yuetao Wen

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引用次数: 0

Abstract

Background

Kidney renal clear cell carcinoma (KIRC), with low survival rate, is the most frequent subtype of renal cell carcinoma. Recently, more and more studies indicate that cuproptosis-related genes (CRGs) and long non-coding RNAs (lncRNAs) play a vital role in the occurrence and development of many types of cancers. However, the roles of cuproptosis-related lncRNAs (CRlncRNAs) in the KIRC was uncertain.

Results

In our study, CRlncRNAs were obtained by coexpression between differentially expressed and prognostic CRGs and differentially expressed and prognostic lncRNAs, and an 8-CRlncRNAs (AC007743.1, AC022915.1, AP005136.4, APCDD1L-DT, HAGLR, LINC02027, MANCR and SMARCA5-AS1) risk model was established according to least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression. This risk model could differentiate immune cell infiltration, immune function and gene mutation.

Conclusions

This 8-CRlncRNAs risk model may be promising for the clinical prediction of prognoses, tumor immune, immunotherapy response and chemotherapeutic response in KIRC patients.

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鉴定杯突相关lncRNAs特征以预测肾透明细胞癌患者的预后

背景肾透明细胞癌（KIRC）生存率低，是肾细胞癌中最常见的亚型。最近，越来越多的研究表明，杯突相关基因（CRGs）和长非编码 RNAs（lncRNAs）在多种癌症的发生和发展中起着重要作用。结果在我们的研究中，通过差异表达和预后的 CRGs 与差异表达和预后的 lncRNAs 的共表达获得了 CRlncRNAs，并得到了 8 个 CRlncRNAs（AC007743.1、AC022915.1、AP005136.4、APCDD1L-DT、HAGLR、LINC02027、MANCR和SMARCA5-AS1）的风险模型。结论该 8-CRlncRNAs 风险模型有望用于 KIRC 患者预后、肿瘤免疫、免疫治疗反应和化疗反应的临床预测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Genetic Engineering and Biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

5.70

自引率

5.70%

发文量

159

审稿时长

16 weeks

期刊介绍： Journal of genetic engineering and biotechnology is devoted to rapid publication of full-length research papers that leads to significant contribution in advancing knowledge in genetic engineering and biotechnology and provide novel perspectives in this research area. JGEB includes all major themes related to genetic engineering and recombinant DNA. The area of interest of JGEB includes but not restricted to: •Plant genetics •Animal genetics •Bacterial enzymes •Agricultural Biotechnology, •Biochemistry, •Biophysics, •Bioinformatics, •Environmental Biotechnology, •Industrial Biotechnology, •Microbial biotechnology, •Medical Biotechnology, •Bioenergy, Biosafety, •Biosecurity, •Bioethics, •GMOS, •Genomic, •Proteomic JGEB accepts