GH therapy in children with juvenile idiopathic arthritis: a four-decade review.

IF 1 Q4 ENDOCRINOLOGY & METABOLISM
Clinical Pediatric Endocrinology Pub Date : 2024-01-01 Epub Date: 2023-12-02 DOI:10.1297/cpe.2023-0036
Giulia Sassano, Saverio La Bella, Armando Di Ludovico, Luciana Breda, Francesco Chiarelli
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引用次数: 0

Abstract

Chronic inflammatory conditions, such as juvenile idiopathic arthritis, are associated with growth failure. Growth failure appears to be correlated with both the effects of inflammation and negative effects of glucocorticoids (used as therapeutic option) on the growth hormone axis and locally on the growth plate and bone metabolism. In the last decade, the introduction of biologics has changed the disease course regarding consequences and outcomes. Anyway in some cases, treatment with biologics has failed in restoring normal growth in patients with juvenile idiopathic arthritis; in contrast, several studies have reported improved height velocity and growth rate in patients with juvenile idiopathic arthritis treated with growth hormone. This study aimed to evaluate the impact of growth hormone treatment on the growth and pubertal development in juvenile idiopathic arthritis patients through a narrative review of the literature over the last four decades.

幼年特发性关节炎患儿的 GH 治疗:四十年回顾。
慢性炎症(如幼年特发性关节炎)与生长迟缓有关。生长迟缓似乎与炎症的影响和糖皮质激素(作为治疗选择)对生长激素轴的负面影响以及对生长板和骨代谢的局部影响有关。在过去的十年中,生物制剂的引入改变了疾病进程的后果和结果。然而,在某些情况下,使用生物制剂治疗未能使特发性幼年关节炎患者恢复正常生长;相反,有几项研究报告称,使用生长激素治疗的特发性幼年关节炎患者的身高速度和生长率有所提高。本研究旨在通过回顾过去四十年的文献,评估生长激素治疗对幼年特发性关节炎患者生长和青春期发育的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Pediatric Endocrinology
Clinical Pediatric Endocrinology ENDOCRINOLOGY & METABOLISM-
CiteScore
2.40
自引率
7.10%
发文量
34
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