{"title":"Pharmacological effects of pentacyclic triterpenoids isolated from Centella asiatica","authors":"","doi":"10.1007/s13580-023-00561-8","DOIUrl":null,"url":null,"abstract":"<h3>Abstract</h3> <p><em>Centella asiatica</em> (CA) is one of the most popular traditional herbal medicines worldwide. It has been used for centuries in many countries, especially for curing skin damage, and is now applied to treat various human diseases. There are various types of triterpenoids from <em>Centella asiatica</em>, with four pentacyclic triterpenoids with the main properties being shown by four pentacyclic triterpenoids: asiaticoside, madecassoside, asiatic acid, and madecassic acid. These terpenoids have similar structures, however each has a slightly different properties. Asiaticoside, madecassoside, asiatic acid, and madecassic acid are synthesized through the isoprenoid pathway known as mevalonate pathway to produce hydrophobic triterpenoid structures (aglycone) which contain hydrophilic sugar chains (glycone). Furthermore, asiaticoside and madecassoside are distinguished by a glycone, and asiatic acid and madecassic acid are distinguished by a aglycone. These pentacyclic triterpenoids have a wide spectrum of beneficial effects and have been used as anti-inflammatories, skin wound treatments, scar treatments, and cosmetics agents. This review aimed to provide a description of the four compounds, of their structure, pharmacological properties, applications in the treatment of various diseases, known mechanisms of action, and commentary on industrial applications.</p>","PeriodicalId":13123,"journal":{"name":"Horticulture Environment and Biotechnology","volume":"299 1","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Horticulture Environment and Biotechnology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1007/s13580-023-00561-8","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 0
Abstract
Centella asiatica (CA) is one of the most popular traditional herbal medicines worldwide. It has been used for centuries in many countries, especially for curing skin damage, and is now applied to treat various human diseases. There are various types of triterpenoids from Centella asiatica, with four pentacyclic triterpenoids with the main properties being shown by four pentacyclic triterpenoids: asiaticoside, madecassoside, asiatic acid, and madecassic acid. These terpenoids have similar structures, however each has a slightly different properties. Asiaticoside, madecassoside, asiatic acid, and madecassic acid are synthesized through the isoprenoid pathway known as mevalonate pathway to produce hydrophobic triterpenoid structures (aglycone) which contain hydrophilic sugar chains (glycone). Furthermore, asiaticoside and madecassoside are distinguished by a glycone, and asiatic acid and madecassic acid are distinguished by a aglycone. These pentacyclic triterpenoids have a wide spectrum of beneficial effects and have been used as anti-inflammatories, skin wound treatments, scar treatments, and cosmetics agents. This review aimed to provide a description of the four compounds, of their structure, pharmacological properties, applications in the treatment of various diseases, known mechanisms of action, and commentary on industrial applications.
期刊介绍：
Horticulture, Environment, and Biotechnology (HEB) is the official journal of the Korean Society for Horticultural Science, was launched in 1965 as the "Journal of Korean Society for Horticultural Science".
HEB is an international journal, published in English, bimonthly on the last day of even number months, and indexed in Biosys Preview, SCIE, and CABI.
The journal is devoted for the publication of original research papers and review articles related to vegetables, fruits, ornamental and herbal plants, and covers all aspects of physiology, molecular biology, biotechnology, protected cultivation, postharvest technology, and research in plants related to environment.
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