{"title":"Hemorphins—a Family of Atypical Opioid Peptides","authors":"F. P. Sarukhanyan, O. V. Hunanyan, H. H. Zakaryan","doi":"10.1134/s1819712423040207","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Hemorphins are a family of endogenous atypical opioid peptides released during the sequential cleavage of hemoglobin β-chain. Hemorphins are widely distributed in the organism and are implicated in pathophysiology of several diseases, including diabetes, cancer, Alzheimer disease and others. These peptides were identified several decades ago and their diverse therapeutic effects have been revealed. However, the exact molecular mechanisms involved in synthesis, metabolism and therapeutic effect of hemorphins are not fully understood. In this review, the current knowledge of hemorphins, focusing on their biological activity and Ca<sup>2+</sup>/CaM/CN-signaling pathway, involved in mechanisms of hemophins action is briefly summarized. These peptides have been intensively investigated at the Institute of Biochemistry (Armenia), and fundamental results are thoroughly discussed in this review.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurochemical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1134/s1819712423040207","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Hemorphins are a family of endogenous atypical opioid peptides released during the sequential cleavage of hemoglobin β-chain. Hemorphins are widely distributed in the organism and are implicated in pathophysiology of several diseases, including diabetes, cancer, Alzheimer disease and others. These peptides were identified several decades ago and their diverse therapeutic effects have been revealed. However, the exact molecular mechanisms involved in synthesis, metabolism and therapeutic effect of hemorphins are not fully understood. In this review, the current knowledge of hemorphins, focusing on their biological activity and Ca2+/CaM/CN-signaling pathway, involved in mechanisms of hemophins action is briefly summarized. These peptides have been intensively investigated at the Institute of Biochemistry (Armenia), and fundamental results are thoroughly discussed in this review.
期刊介绍：
Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components.
The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.
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