The relationship between self-perceived fatigue, muscle endurance, and circulating markers of inflammation in participants of the Copenhagen aging and Midlife Biobank (CAMB)

IF 3.7 1区医学 Q2 GERIATRICS & GERONTOLOGY

European Review of Aging and Physical Activity Pub Date : 2024-01-31 DOI:10.1186/s11556-024-00336-9

Ivan Bautmans, Veerle Knoop, Ingo Beyer, Helle Bruunsgaard, Drude Molbo, Erik Lykke Mortensen, Rikke Lund

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引用次数: 0

Abstract

Fatigue, low muscle endurance, muscle weakness and low-grade inflammation are strongly related to frailty at higher age. When signs of self-perceived fatigue and low muscle endurance are interrelated with low-grade inflammation at midlife, they might be used as early markers for frailty. This study investigated whether the interrelationships among self-perceived fatigue, muscle endurance and inflammation can be observed at midlife. A total of 965 participants of the Copenhagen Aging and Midlife Biobank (aged 52 ± 4 years, 536 males, 426 females) were assessed for self-perceived fatigue (20-item multidimensional fatigue inventory), muscle endurance (grip work), circulating markers of inflammation (hsCRP, IL-6, IL-10, TNF-alpha and IFN-γ), daily physical activity (PAS-2), body composition (%body fat assessed by bio-impedance) and self-reported health status. Participants were categorised (correcting for age and gender) according to high fatigue and/or low muscle endurance, differences in inflammatory profile between fatigue categories were assessed by ANCOVA (corrected for PAS-2, %body fat and presence of inflammatory conditions). Overall, muscle endurance, fatigue and inflammatory markers were significantly interrelated. Higher levels of hsCRP (p < 0.001), IL-6 (p < 0.001), IL-10 (p = 0.035) and TNF-alpha (p = 0.028) were observed in participants presenting both low muscle endurance and high fatigue. IFN-γ was highest in those with high fatigue but normal muscle endurance (p = 0.015). Middle-aged participants with higher fatigue in combination with low muscle endurance show higher levels of inflammation, independently from physical activity, body fat and inflammatory pathology. The underlying mechanisms should be identified and future studies should also investigate whether these individuals show early signs of reduced physiological reserve capacity, which in later life come to full expression by means of frailty.

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哥本哈根中老年生物数据库（CAMB）参与者的自我感觉疲劳、肌肉耐力和循环炎症标记物之间的关系

疲劳、肌肉耐力低下、肌肉无力和低度炎症与高龄虚弱密切相关。当自我感觉疲劳和肌肉耐力低下的迹象与中年期的低度炎症相互关联时，它们可能被用作体弱的早期标志物。本研究探讨了在中年是否可以观察到自我感觉疲劳、肌肉耐力和炎症之间的相互关系。研究人员对哥本哈根老龄化和中年生物库中的 965 名参与者（年龄为 52 ± 4 岁，男性 536 人，女性 426 人）进行了自我感觉疲劳（20 项多维疲劳量表）、肌肉耐力（握力）、炎症循环标志物（hsCRP、IL-6、IL-10、TNF-α 和 IFN-γ）、日常体力活动（PAS-2）、身体成分（通过生物阻抗评估体脂百分比）和自我健康状况评估。根据高疲劳度和/或低肌肉耐力对参与者进行分类（校正年龄和性别），并通过方差分析（校正 PAS-2、体脂百分比和炎症状况）评估疲劳类别之间炎症状况的差异。总体而言，肌肉耐力、疲劳和炎症指标之间存在显著的相互关联。在肌肉耐力低和疲劳度高的参与者中观察到较高水平的 hsCRP（p < 0.001）、IL-6（p < 0.001）、IL-10（p = 0.035）和 TNF-α（p = 0.028）。IFN-γ在高疲劳但肌肉耐力正常的参与者中含量最高（p = 0.015）。疲劳度较高且肌肉耐力较低的中年参与者的炎症水平较高，这与体力活动、体脂和炎症病理无关。应找出其潜在的机制，未来的研究还应调查这些人是否表现出生理储备能力降低的早期迹象，并在晚年通过虚弱的方式充分表现出来。

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来源期刊

European Review of Aging and Physical Activity 医学-老年医学

CiteScore

8.60

自引率

1.60%

发文量

审稿时长

>12 weeks

期刊介绍： European Review of Aging and Physical Activity (EURAPA) disseminates research on the biomedical and behavioural aspects of physical activity and aging. The main issues addressed by EURAPA are the impact of physical activity or exercise on cognitive, physical, and psycho-social functioning of older people, physical activity patterns in advanced age, and the relationship between physical activity and health.