Postexercise reflex facilitation in Lambert-Eaton myasthenic syndrome.

IF 2.4 Q2 CLINICAL NEUROLOGY
Mervyn Poh, Yeo Chong Ming, Patricia Cheong Yanni, Gee Jin Ng, Yong Howe Ho, Kalpana Prasad, Umapathi Thirugnanam
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引用次数: 0

Abstract

A 62-year-old woman had 6 months of proximal weakness, fatigue and occasional diplopia, symptoms normally suggesting myasthenia gravis or inflammatory myopathy. Postexercise reflex facilitation is a bedside clinical sign that points to a diagnosis of the rarer alternative, Lambert-Eaton myasthenic syndrome (LEMS). We confirmed this diagnosis using electrodiagnostic short exercise testing and serum assay for voltage-gated calcium channel antibodies. Further investigation identified a small cell neuroendocrine carcinoma of the gallbladder, not previously associated with LEMS. Postexercise reflex facilitation is an important bedside clinical finding that helps clinicians to distinguish LEMS from its mimics.

兰伯特-伊顿肌无力综合征的运动后反射促进。
一名 62 岁的妇女出现近端乏力、疲劳和偶尔复视症状已有 6 个月,这些症状通常提示她患有重症肌无力或炎症性肌病。运动后反射促进是一种床旁临床症状,可诊断为较罕见的另一种病--兰伯特-伊顿肌萎缩综合征(LEMS)。我们通过电诊断短程运动测试和血清电压门控钙通道抗体检测证实了这一诊断。进一步检查发现,患者患有胆囊小细胞神经内分泌癌,这与 LEMS 之前并无关联。运动后反射促进是一项重要的床旁临床发现,有助于临床医生区分LEMS和其模拟症状。
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来源期刊
PRACTICAL NEUROLOGY
PRACTICAL NEUROLOGY Medicine-Neurology (clinical)
CiteScore
3.70
自引率
3.60%
发文量
113
期刊介绍: The essential point of Practical Neurology is that it is practical in the sense of being useful for everyone who sees neurological patients and who wants to keep up to date, and safe, in managing them. In other words this is a journal for jobbing neurologists - which most of us are for at least part of our time - who plough through the tension headaches and funny turns week in and week out. Primary research literature potentially relevant to routine clinical practice is far too much for any neurologist to read, let alone understand, critically appraise and assimilate. Therefore, if research is to influence clinical practice appropriately and quickly it has to be digested and provided to neurologists in an informative and convenient way.
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