A Single-Center Retrospective Analysis of Kaposi's Sarcoma: Is There a Relationship Between Emmprin/CD147 Expression and Biological Behavior?

IF 0.9 4区医学 Q4 PATHOLOGY

International Journal of Surgical Pathology Pub Date : 2024-10-01 Epub Date: 2024-01-30 DOI:10.1177/10668969241226711

Zarifa Yusifli, Rashad Ismayilov, Kemal Kosemehmetoglu, Gokhan Gedikoglu

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引用次数: 0

Abstract

Objectives: Emmprin (CD147/BSG) protein is estimated to play a key role in cell migration and chemoresistance in viral carcinogenesis. However, there are very limited studies investigating the CD147 in the oncogenesis of Kaposi's sarcoma-associated herpesvirus. This study aims to reveal the relationship between CD147 expression with histopathological parameters, disease pattern, and recurrence in Kaposi's sarcoma (KS).

Methods: The study included 67 patients diagnosed with KS between January 1982 and September 2023. Clinical and histopathological features were analyzed retrospectively. HHV-8, CD31, and CD147 expressions were evaluated by immunohistochemistry.

Results: Sixteen (24%) female and 51 (76%) male patients with median age of 64 (10-86) were included in the study. CD147 was positive in 57 (85%) cases and associated with nodular pattern (P = .001), presence of solid/fibrosarcomatous area (P = .005), and high mitotic activity (P = .035). The disease relapsed in 17 (27%) of the 63 patients with median 2 (0-12) years follow-up. While a 5-year relapse-free survival was 48.5% in the CD147 diffuse positive group, it was 83.4% in focal positive and 100% in negative cases (P = .029).

Conclusion: Our study exhibited the relationship between CD147 overexpression and recurrence in KS, but the inhomogeneity of the treatment groups and the small number of patients should also be considered. These findings may provide insight into the pathogenesis of KS and the development of targeted therapies in the future.

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卡波西肉瘤的单中心回顾性分析：Emmprin/CD147 表达与生物学行为之间有关系吗？

目的：据估计，Emmprin（CD147/BSG）蛋白在病毒致癌过程中的细胞迁移和化疗抵抗中发挥着关键作用。然而，有关 CD147 在卡波西肉瘤相关疱疹病毒致癌过程中的作用的研究非常有限。本研究旨在揭示 CD147 表达与卡波西肉瘤（KS）组织病理学参数、疾病模式和复发之间的关系：研究纳入了1982年1月至2023年9月期间确诊的67例卡波济氏肉瘤患者。回顾性分析了临床和组织病理学特征。免疫组化法评估了 HHV-8、CD31 和 CD147 的表达：16例（24%）女性患者和51例（76%）男性患者参与了研究，中位年龄为64（10-86）岁。57例（85%）患者的CD147呈阳性，与结节型（P = .001）、实变/纤维肉瘤区（P = .005）和高有丝分裂活性（P = .035）有关。63 名患者中有 17 人（27%）复发，中位随访时间为 2（0-12）年。CD147弥漫阳性组的5年无复发生存率为48.5%，而局灶阳性组为83.4%，阴性组为100%（P = .029）：我们的研究显示了 CD147 过度表达与 KS 复发之间的关系，但也应考虑到治疗组的不均匀性和患者人数较少的因素。这些发现可能有助于深入了解 KS 的发病机制，并在未来开发靶向疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Surgical Pathology 医学-病理学

CiteScore

2.10

自引率

0.00%

发文量

198

审稿时长

1 months

期刊介绍： International Journal of Surgical Pathology (IJSP) is a peer-reviewed journal published eight times a year, which offers original research and observations covering all major organ systems, timely reviews of new techniques and procedures, discussions of controversies in surgical pathology, case reports, and images in pathology. This journal is a member of the Committee on Publication Ethics (COPE).