Appetitive and psychological phenotypes of pediatric patients with obesity

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2024-01-30 DOI:10.1111/ijpo.13101

Claudia K. Fox, Stephen J. Molitor, David M. Vock, Carol B. Peterson, Scott J. Crow, Amy C. Gross

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引用次数: 0

Abstract

Background

Obesity is a heterogeneous disease with variable treatment response. Identification of the unique constellation of contributors to obesity may allow for targeted interventions and improved outcomes.

Objective

Identify empirically derived phenotypes of pediatric patients with obesity based on appetitive and psychological correlates of obesity.

Methods

This cross-sectional study included patients aged 5–12 years who were treated in a weight management clinic and completed standard intake questionnaires including Child Eating Behavior Questionnaire (CEBQ), Vanderbilt ADHD Scale and Pediatric Symptom Checklist. Phenotypes were elicited using latent profile analysis of 12 indicators: eight CEBQ subscales, inattention, hyperactivity/impulsivity, internalizing and externalizing symptoms.

Results

Parents/guardians of 384 patients (mean age 9.8 years, mean BMI 30.3 kg/m²) completed the intake questionnaires. A 4-phenotype model best fits the data. Hedonic Impulsive phenotype (42.5%) exhibited high food enjoyment and hyperactivity/impulsivity. Inattentive Impulsive phenotype (27.4%) exhibited overall low food approach and high food avoid behaviours, and highest inattention. Hedonic Emotional phenotype (20.8%) scored the highest on food enjoyment, internalizing and externalizing symptoms. Picky Eating phenotype (9.3%) scored the lowest on food approach, inattention, hyperactivity/impulsivity, internalizing and externalizing symptoms.

Conclusion

Appetitive traits and psychological symptoms appear to cluster in distinct patterns, giving rise to four unique phenotypic profiles, which, if replicated, may help inform the development of tailored treatment plans.

Abstract Image

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儿科肥胖症患者的食欲和心理表型。

背景：肥胖症是一种异质性疾病，对治疗的反应各不相同。确定导致肥胖的独特因素可能有助于采取有针对性的干预措施并改善治疗效果：根据肥胖的食欲和心理相关因素，确定儿科肥胖症患者的经验表型：这项横断面研究纳入了在体重管理诊所接受治疗的 5-12 岁患者，他们填写了标准的入院问卷，包括儿童进食行为问卷 (CEBQ)、范德比尔特多动症量表和儿科症状检查表。通过对12个指标（CEBQ的8个分量表、注意力不集中、多动/冲动、内化症状和外化症状）进行潜在特征分析，得出表型：384名患者（平均年龄9.8岁，平均体重指数30.3 kg/m2）的家长/监护人填写了入组问卷。4种表型模型最符合数据。享乐型冲动表型（42.5%）表现出高度的食物享受和多动/冲动。注意力不集中冲动型表型（27.4%）总体表现为低食物接近行为和高食物回避行为，注意力最不集中。享乐情绪表型（20.8%）在享受食物、内化和外化症状方面得分最高。挑食表型（9.3%）在进食、注意力不集中、多动/冲动、内化和外化症状方面得分最低：结论：食欲特征和心理症状似乎以不同的模式聚集在一起，形成了四种独特的表型特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.