Quality Control and Phytochemical Profiling of a Polyherbal Traditional Indian Medicine by GC-MS method

IF 0.1 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

International Journal of Ayurvedic Medicine Pub Date : 2024-01-07 DOI:10.47552/ijam.v14i4.3875

Payal Raut, B. Rathi, Renu Rathi, Piyush Chaudhary

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Abstract

Introduction: Gomutra (Cow's urine) has been described to be the most effective substance of animal origin. It is useful in treating various diseases due to its pharmacological activities. Nevertheless, due to its pungent smell, palatability, shelf life and fresh availability have always remained a problem. So it is very much essential to modify it into different dosage forms. One of its traditional dosage forms is Gomutrasava, an alcoholic fermented product indicated in the management of Shvitra (vitiligo). Aim & objective: The study is planned for Pharmaceutical preparation and quality control assessment of Gomutrasava. Material & Methods: Gomutrasava was prepared according to a reference from Astanga Hrudaya. This formulation was tested for organoleptic characters and physicochemical parameters, including Gas Chromatography-Mass Spectrometry (GC-MS). Observation & Results: After fermentation colour of Gomutrasava appeared dark brown with specific cow urine smell. pH, specific gravity at 25ºC, reftractive index, brix, viscocity, total solid content, alcohol content, reducing sugar, non reducing sugar of Gomutrasava were 5.41, 0.967 wt/ml, 1.394, 37º, 1.38/sec, 37%, 6%, 0.96%, 0.07% respectively and test for methanol and microbial contamination were negative. GC-MS revealed some compounds attributed to antimicrobial, anticancerous and antifungal activities. Conclusion Thus this data combined with analytical data will be used for clinical study and treatment of Shvitra (Vitiligo), Kushtha (Leprosy) and various skin diseases.

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用 GC-MS 方法对印度传统多草药进行质量控制和植物化学成分分析

简介Gomutra（牛尿）被认为是最有效的动物源性物质。由于其药理作用，它可用于治疗各种疾病。然而，由于其刺激性气味、适口性、保质期和新鲜度一直是个问题。因此，将其改良成不同的剂型非常重要。Gomutrasava 就是其传统剂型之一，它是一种酒精发酵产品，可用于治疗 Shvitra（白癜风）。目的和目标：本研究计划对 Gomutrasava 进行药物制备和质量控制评估。材料与方法：根据 Astanga Hrudaya 的参考资料配制 Gomutrasava。对该制剂进行了感官特征和理化参数测试，包括气相色谱-质谱法（GC-MS）。观察与结果： Gomutrasava 的 pH 值、25ºC 时的比重、折光率、糖度、粘度、总固形物含量、酒精含量、还原糖、非还原糖分别为 5.41、0.967 wt/ml、1.394、37º、1.38/sec、37%、6%、0.96%、0.07%，甲醇和微生物污染检测呈阴性。气相色谱-质谱（GC-MS）显示，一些化合物具有抗菌、抗癌和抗真菌活性。结论因此，这些数据与分析数据相结合，将用于临床研究和治疗 Shvitra（白癜风）、Kushtha（麻风病）和各种皮肤病。

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来源期刊

International Journal of Ayurvedic Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

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50.00%

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