Risk Factors Of Ovarian Cancer Among The Postmenopausal Women

Journal of Preventive and Social Medicine Pub Date : 2024-01-08 DOI:10.3329/jopsom.v41i2.69544

Mosfika Rahman, Parveen Shahida Akhtar, N. Khatun, Md Mahmudul Hasan, Anm Shamsul Islam, Fatima Sarker, Narita Khurshid, Tanzina Hossain, Md Nahid Hossen, Mahfuza Rahman

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Abstract

Background: Ovarian cancer ranks 5thin cancer deaths among women. A woman’s risk of getting ovarian cancer during her lifetime is about 1 in 75. Cancer mainly develops in older women. Methods: The case control study was carried out among 154 respondents in medical oncology department, NIRCH, Dhaka from July 2016 to June 2017. Among the participants, 77 were cases who had ovarian cancer and another 77 were controls who had no ovarian cancer. Convenient sampling technique was used and data were collected by face-to-face interview using a pretested semi-structured questionnaire. Data were entered on to the template of SPSS and analysis was done. Results: The mean age of case and control group were 60.06±7.00 and 59.89±6.96 years respectively. Highest number of respondents were illiterate. Majority came from rural area and had no personal monthly income. Most of them were taken high fiber diet, 83.1% in case and 77.9% in control group. About 80.5% in case and 66.2% in control group had BMI ≥25 kg/m2. Sedentary workers 40.3% in case and 13.0% in control group; moderate workers were 31.2% in case and 20.8% in control group and hard workers were 28.5% and 66.2% in case and control group respectively. The mean age of menarche 12.02±1.19 years and 12.87±1.30 years in case and control group respectively and mean age of menopause in case and in control groups respectively 51.54±2.39 and 49.61±1.29 years. In case group 49.3% had early term pregnancy whereas in control group 9.5% had early term pregnancy; in case group 82.1% and in control group 86.5% had breast feeding history. Around 16.9% in case group and 27.3% in control group used to take OCP. Significantly more respondents 6.5% in case group had personal H/O breast cancer than control group. Positive family history of breast and ovarian cancer was found 16.9% in case group and 2.6% in control group. In binary logistic regression analysis for risk factors of OC was found that sedentary activity was associated with increased risk, increased BMI (≥25 kg/m2), early age of menarche (≤12 years), late age of menopause (>51 years), nullipara and early term pregnancy. Family H/O breast or ovarian cancer significantly associated with development of ovarian cancer. Conclusion: Ovarian cancer observed more in older age group (≥60 years) among sedentary worker with high body mass index (≥25 kg/m2). Early age of menarche (≤12 years), late menopause (>50 years), never having given birth to a child in life time, early term of pregnancy and family history of breast and ovarian cancer were significantly associated with ovarian cancer among post-menopausal women. JOPSOM 2021; 41(2):28-35

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绝经后妇女患卵巢癌的风险因素

背景：卵巢癌在女性癌症死亡人数中排名第五。妇女一生中患卵巢癌的风险约为 1/75。癌症主要发生在老年妇女身上。研究方法病例对照研究于 2016 年 7 月至 2017 年 6 月在达卡国家康复中心肿瘤内科对 154 名受访者进行了调查。参与者中，77 人为卵巢癌病例，另外 77 人为未患卵巢癌的对照组。研究采用了方便抽样技术，并通过预先测试的半结构化问卷进行面对面访谈收集数据。数据输入 SPSS 模板并进行分析。结果病例组和对照组的平均年龄分别为 60.06±7.00 岁和 59.89±6.96 岁。受访者中文盲最多。大多数来自农村地区，没有个人月收入。大多数受访者都食用高纤维饮食，病例组和对照组分别为 83.1%和 77.9%。病例组和对照组中分别有 80.5%和 66.2%的人体重指数≥25 kg/m2。久坐不动的工人在病例中占 40.3%，在对照组中占 13.0%；中等体力劳动者在病例中占 31.2%，在对照组中占 20.8%；体力劳动者在病例中占 28.5%，在对照组中占 66.2%。病例组和对照组的平均初潮年龄分别为（12.02±1.19）岁和（12.87±1.30）岁，病例组和对照组的平均绝经年龄分别为（51.54±2.39）岁和（49.61±1.29）岁。病例组中有 49.3%的人有过早孕史，而对照组中只有 9.5%的人有过早孕史；病例组中有 82.1%的人有过母乳喂养史，而对照组中只有 86.5%的人有母乳喂养史。病例组中约有 16.9%的人服用过 OCP，对照组中约有 27.3%的人服用过 OCP。与对照组相比，病例组中有 6.5%的受访者曾患H/O型乳腺癌。病例组中有乳腺癌和卵巢癌阳性家族史的占 16.9%，对照组占 2.6%。在对卵巢癌风险因素的二元逻辑回归分析中发现，久坐不动、体重指数增加（≥25 kg/m2）、月经初潮年龄早（≤12 岁）、绝经年龄晚（>51 岁）、无子宫和早产与风险增加有关。家族中曾患/未患乳腺癌或卵巢癌者与卵巢癌的发生密切相关。结论在高体重指数（≥25 kg/m2）的久坐工作者中，年龄较大（≥60 岁）的人更容易患卵巢癌。绝经后妇女月经初潮年龄早（≤12 岁）、绝经晚（>50 岁）、一生中从未生育过子女、妊娠过早以及有乳腺癌和卵巢癌家族史与卵巢癌有显著相关性。JOPSOM 2021; 41(2):28-35

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Journal of Preventive and Social Medicine

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