Margaret Brimble, Ze Kuang, Xiaobo Ding, D. Furkert
{"title":"Synthesis and alpha-Functionalisation of Cyclic Imines","authors":"Margaret Brimble, Ze Kuang, Xiaobo Ding, D. Furkert","doi":"10.1055/a-2251-4145","DOIUrl":null,"url":null,"abstract":"-Functionalisation of cyclic imines has been explored. The cyclic imine substrates were synthesised from their respective halonitrile precursors using a nucleophilic addition/cyclisation sequence. Selective monohalogenation of the cyclic imines yielded alpha-haloimines, which served as a platform to obtain various alpha-hydroxyimine derivatives. In addition, an unusual tautomerisation and oxidation sequence was observed in the attempted preparation of alpha-hydroxyimines.","PeriodicalId":509029,"journal":{"name":"Synlett","volume":"27 13","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synlett","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/a-2251-4145","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
-Functionalisation of cyclic imines has been explored. The cyclic imine substrates were synthesised from their respective halonitrile precursors using a nucleophilic addition/cyclisation sequence. Selective monohalogenation of the cyclic imines yielded alpha-haloimines, which served as a platform to obtain various alpha-hydroxyimine derivatives. In addition, an unusual tautomerisation and oxidation sequence was observed in the attempted preparation of alpha-hydroxyimines.