The Gut Microbiome Correlated to Chemotherapy Efficacy in Diffuse Large B-Cell Lymphoma Patients

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-22 DOI:10.3390/hematolrep16010007

Zhuo-Fan Xu, Li Yuan, Yan Zhang, Wei Zhang, C. Wei, Wei Wang, Dan Zhao, D. Zhou, Jingnan Li

引用次数: 0

Abstract

The gut microbiome (GMB) has been extensively reported to be associated with the development and prognosis of human diseases. This study aims to investigate the relationship between GMB composition and chemotherapy efficacy in diffuse large B-cell lymphoma (DLBCL). We demonstrated that DLBCL patients at diagnosis have altered GMB compositions. Significant enrichment of the Proteobacteria phylum in DLBCL patients was observed. Gene analysis showed a high abundance of virulence factors genes. We found baseline GMB to be associated with clinical outcomes. The emergence of Lactobacillus fermentum was correlated with better treatment outcome. Our pilot results suggested a correlation between GMB composition and DLBCL development and prognosis. Clues from our study, together with previous research, provided a rational foundation for further investigation on the pathogenesis, prognosis value, and targeted therapy of GMB in DLBCL.

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弥漫大 B 细胞淋巴瘤患者肠道微生物组与化疗疗效的关系

肠道微生物组（GMB）被广泛报道与人类疾病的发生和预后有关。本研究旨在探讨弥漫大B细胞淋巴瘤（DLBCL）中肠道微生物组的组成与化疗疗效之间的关系。我们发现，弥漫大 B 细胞淋巴瘤患者在确诊时的 GMB 组成发生了改变。我们观察到，DLBCL 患者体内的蛋白杆菌门显著富集。基因分析显示，毒力因子基因的丰度很高。我们发现基线 GMB 与临床结果相关。发酵乳杆菌的出现与更好的治疗效果相关。我们的试验结果表明，GMB的组成与DLBCL的发展和预后有关。我们的研究以及之前的研究为进一步研究 DLBCL 中 GMB 的发病机制、预后价值和靶向治疗提供了合理的依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.