Neuromelanin-sensitive magnetic resonance imaging in the study of mental disorder: A systematic review

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging Pub Date : 2024-01-26 DOI:10.1016/j.pscychresns.2024.111785

Qiuyu Lv , Xuanyi Wang , Pan Lin , Xiang Wang

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引用次数: 0

Abstract

Dopamine and norepinephrine are implicated in the pathophysiology of mental disorders, but non-invasive study of their neuronal function remains challenging. Recent research suggests that neuromelanin-sensitive magnetic resonance imaging (NM-MRI) techniques may overcome this limitation by enabling the non-invasive imaging of the substantia nigra (SN)/ ventral tegmental area (VTA) dopaminergic and locus coeruleus (LC) noradrenergic systems. A review of 19 studies that met the criteria for NM-MRI application in mental disorders found that despite the use of heterogeneous sequence parameters and metrics, nearly all studies reported differences in contrast ratio (CNR) of LC or SN/VTA between patients with mental disorders and healthy controls. These findings suggest that NM-MRI is a valuable tool in psychiatry, but the differences in sequence parameters across studies hinder comparability, and a standardized analysis pipeline is needed to improve the reliability of results. Further research using standardized methods is needed to better understand the role of dopamine and norepinephrine in mental disorders.

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神经黑素敏感磁共振成像在精神障碍研究中的应用：系统回顾

多巴胺和去甲肾上腺素与精神障碍的病理生理学有关，但对它们的神经元功能进行非侵入性研究仍具有挑战性。最近的研究表明，神经黑素敏感磁共振成像（NM-MRI）技术可以克服这一限制，对黑质（SN）/腹侧被盖区（VTA）多巴胺能系统和脑室（LC）去甲肾上腺素能系统进行无创成像。对符合 NM-MRI 应用于精神障碍标准的 19 项研究进行回顾后发现，尽管使用了不同的序列参数和指标，但几乎所有研究都报告了精神障碍患者与健康对照组之间 LC 或 SN/VTA 对比度（CNR）的差异。这些研究结果表明，NM-MRI 是精神病学的一种有价值的工具，但不同研究中序列参数的差异阻碍了其可比性，因此需要标准化的分析管道来提高结果的可靠性。要更好地了解多巴胺和去甲肾上腺素在精神障碍中的作用，还需要使用标准化方法开展进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Research: Neuroimaging 医学-精神病学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

22.5 weeks

期刊介绍： The Neuroimaging section of Psychiatry Research publishes manuscripts on positron emission tomography, magnetic resonance imaging, computerized electroencephalographic topography, regional cerebral blood flow, computed tomography, magnetoencephalography, autoradiography, post-mortem regional analyses, and other imaging techniques. Reports concerning results in psychiatric disorders, dementias, and the effects of behaviorial tasks and pharmacological treatments are featured. We also invite manuscripts on the methods of obtaining images and computer processing of the images themselves. Selected case reports are also published.