Genome-edited rabbits: Unleashing the potential of a promising experimental animal model across diverse diseases.

IF 4 1区生物学 Q1 ZOOLOGY

Zoological Research Pub Date : 2024-03-18 DOI:10.24272/j.issn.2095-8137.2023.201

Yang Han, Jiale Zhou, Renquan Zhang, Yuru Liang, Liangxue Lai, Zhanjun Li

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引用次数: 0

Abstract

Animal models are extensively used in all aspects of biomedical research, with substantial contributions to our understanding of diseases, the development of pharmaceuticals, and the exploration of gene functions. The field of genome modification in rabbits has progressed slowly. However, recent advancements, particularly in CRISPR/Cas9-related technologies, have catalyzed the successful development of various genome-edited rabbit models to mimic diverse diseases, including cardiovascular disorders, immunodeficiencies, aging-related ailments, neurological diseases, and ophthalmic pathologies. These models hold great promise in advancing biomedical research due to their closer physiological and biochemical resemblance to humans compared to mice. This review aims to summarize the novel gene-editing approaches currently available for rabbits and present the applications and prospects of such models in biomedicine, underscoring their impact and future potential in translational medicine.

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基因组编辑兔：释放有潜力的实验动物模型在各种疾病中的潜能。

动物模型被广泛应用于生物医学研究的各个方面，为我们了解疾病、开发药物和探索基因功能做出了巨大贡献。兔子基因组改造领域进展缓慢。然而，最近的进步，特别是 CRISPR/Cas9 相关技术的进步，已经促进了各种基因组编辑兔模型的成功开发，以模拟各种疾病，包括心血管疾病、免疫缺陷、衰老相关疾病、神经系统疾病和眼科疾病。与小鼠相比，这些模型在生理和生化方面更接近人类，因此在推动生物医学研究方面大有可为。本综述旨在总结目前可用于兔子的新型基因编辑方法，并介绍这类模型在生物医学中的应用和前景，强调其在转化医学中的影响和未来潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zoological Research Medicine-General Medicine

CiteScore

7.60

自引率

10.20%

发文量

1937

审稿时长

8 weeks

期刊介绍： Established in 1980, Zoological Research (ZR) is a bimonthly publication produced by Kunming Institute of Zoology, the Chinese Academy of Sciences, and the China Zoological Society. It publishes peer-reviewed original research article/review/report/note/letter to the editor/editorial in English on Primates and Animal Models, Conservation and Utilization of Animal Resources, and Animal Diversity and Evolution.