Structure determination needs to go viral.

IF 3 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Amino Acids Pub Date : 2024-01-29 DOI:10.1007/s00726-023-03374-2

Matheus de Bastos Balbe E Gutierres, Conrado Pedebos, Paula Bacaicoa-Caruso, Rodrigo Ligabue-Braun

引用次数: 0

Abstract

Viral diseases are expected to cause new epidemics in the future, therefore, it is essential to assess how viral diversity is represented in terms of deposited protein structures. Here, data were collected from the Protein Data Bank to screen the available structures of viruses of interest to WHO. Excluding SARS-CoV-2 and HIV-1, less than 50 structures were found per year, indicating a lack of diversity. Efforts to determine viral structures are needed to increase preparedness for future public health challenges.

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结构的确定需要病毒式传播。

预计病毒性疾病将在未来引发新的流行病，因此，评估病毒多样性如何体现在保存的蛋白质结构中至关重要。在此，我们从蛋白质数据库收集数据，筛选世卫组织感兴趣的现有病毒结构。除 SARS-CoV-2 和 HIV-1 外，每年发现的病毒结构不足 50 个，这表明病毒缺乏多样性。需要努力确定病毒结构，以提高应对未来公共卫生挑战的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Amino Acids 生物-生化与分子生物学

CiteScore

6.40

自引率

5.70%

发文量

审稿时长

2.2 months

期刊介绍： Amino Acids publishes contributions from all fields of amino acid and protein research: analysis, separation, synthesis, biosynthesis, cross linking amino acids, racemization/enantiomers, modification of amino acids as phosphorylation, methylation, acetylation, glycosylation and nonenzymatic glycosylation, new roles for amino acids in physiology and pathophysiology, biology, amino acid analogues and derivatives, polyamines, radiated amino acids, peptides, stable isotopes and isotopes of amino acids. Applications in medicine, food chemistry, nutrition, gastroenterology, nephrology, neurochemistry, pharmacology, excitatory amino acids are just some of the topics covered. Fields of interest include: Biochemistry, food chemistry, nutrition, neurology, psychiatry, pharmacology, nephrology, gastroenterology, microbiology