Image-guided point-shear-wave elastography: a valid and reliable technique for liver fibrotic staging.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Ultrasound Pub Date : 2024-06-01 Epub Date: 2024-01-28 DOI:10.1007/s40477-023-00854-9

Sietske Bergsma, Margo van Gent, Alida J Dam-Vervloet, Martine C M Lagerweij, Egbert-Jan van der Wouden, Ingrid M Nijholt, Martijn F Boomsma, Lieke Poot

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引用次数: 0

Abstract

Purpose: Despite progressive implementation of image-guided point-shear wave elastography (pSWE) in guidelines as an alternative to transient elastography for the staging of fibrotic liver disease, pSWE is not widely adopted in clinical workflow. More information on reliability and validity of pSWE systems is needed. Therefore, we performed a phantom study to evaluate the validity and reliability of pSWE with ultrasound systems.

Methods: Validity and reliability of pSWE measurements from three ultrasound systems were evaluated. Measurements were performed on an elasticity phantom with reference elasticities of 7 ± 1 (low) (median ± interquartile range (IQR)), 14 ± 2 (medium) and 26 ± 3 (high) kPa. Measurements were repeated in tenfold for each reference at 2, 3 and 4 cm depth. Results were considered valid when median elasticity ± IQR was between the uncertainty limits (IQR) for each reference elasticity value and reliable when IQR/median < 0.30.

Results: pSWE with the systems provided valid results for all reference elasticities and focal depths, except for overestimation of high reference elasticity at 2 and 4 cm depth for one system (41.5 ± 4.3 and 39.0 ± 1.2 kPa, respectively). Measurements were reliable with a maximum IQR/median of 0.13, well below the guideline of IQR/median < 0.30.

Discussion: The results support the use of pSWE as an alternative to invasive or non-image guided noninvasive techniques for liver fibrotic staging.

Conclusions: pSWE with ultrasound systems from different vendors is valid and reliable and can therefore be implemented to optimize clinical workflow by performing imaging and elastography simultaneously.

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图像引导下的点剪切波弹性成像：一种有效可靠的肝纤维化分期技术。

目的：尽管在指南中逐步采用了图像引导点剪切波弹性成像（pSWE）作为瞬态弹性成像的替代方法来对纤维化肝病进行分期，但 pSWE 并未在临床工作流程中得到广泛采用。我们需要更多有关 pSWE 系统可靠性和有效性的信息。因此，我们进行了一项模型研究，以评估 pSWE 与超声系统的有效性和可靠性：方法：评估了三种超声系统测量 pSWE 的有效性和可靠性。测量在一个弹性模型上进行，参考弹性为 7 ± 1（低）（中位数 ± 四分位数间距 (IQR)）、14 ± 2（中）和 26 ± 3（高）kPa。在 2 厘米、3 厘米和 4 厘米深度重复测量每个参考值的十倍。当弹性中位数 ± IQR 在每个参考弹性值的不确定度范围 (IQR) 之间时，结果被认为是有效的；当 IQR/中位数 < 0.30 时，结果被认为是可靠的。结果：除了一个系统在 2 厘米和 4 厘米深度高估了高参考弹性（分别为 41.5 ± 4.3 和 39.0 ± 1.2 kPa）外，使用该系统进行的 pSWE 为所有参考弹性和病灶深度提供了有效结果。测量结果可靠，最大 IQR/中位数为 0.13，远低于 IQR/中位数 < 0.30 的准则：结论：使用不同供应商的超声系统进行 pSWE 测量是有效和可靠的，因此可以通过同时进行成像和弹性成像来优化临床工作流程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Ultrasound RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

4.10

自引率

15.00%

发文量

133

期刊介绍： The Journal of Ultrasound is the official journal of the Italian Society for Ultrasound in Medicine and Biology (SIUMB). The journal publishes original contributions (research and review articles, case reports, technical reports and letters to the editor) on significant advances in clinical diagnostic, interventional and therapeutic applications, clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and in cross-sectional diagnostic imaging. The official language of Journal of Ultrasound is English.