Skin biophysical parameters and serum dermokine levels in airline pilots: a comparative study with office workers.

IF 1.4 4区 医学 Q3 ALLERGY
Postepy Dermatologii I Alergologii Pub Date : 2023-12-01 Epub Date: 2024-01-08 DOI:10.5114/ada.2023.132262
Piercarlo Minoretti, Andrés S Santiago Sáez, Ángel F García Martín, Miryam Liańo Riera, Manuel Gómez Serrano, Enzo Emanuele
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引用次数: 0

Abstract

Introduction: Concerns are growing in the aviation industry about occupational skin diseases like malignant melanoma (MM) among airline pilots (APs), due to the unique working environment that exposes them to various skin stressors.

Aim: To compare five skin biophysical parameters in a group of 40 male APs, each matched in terms of age and service tenure (minimum of 5 years) with a control group of 40 male office workers (OWs). Considering the potential role of dermokine (DMKN) in skin barrier dysfunction and the pathogenesis of MM, we further analyzed the serum levels of this molecule and correlated them with the measured skin parameters.

Material and methods: Stratum corneum skin hydration, transepidermal water loss (TEWL), sebum content, erythema index (EI), and melanin index (MI) were quantified by non-invasive instruments in the cheek region. Serum DMKN levels were measured using a commercially available enzyme-linked immunosorbent assay kit.

Results: Compared with OWs, the skin of APs exhibited a decrease in hydration levels in the stratum corneum, coinciding with a higher TEWL. However, there was no significant variance in sebum content between the groups. MI was notably higher in APs than in OWs, as was EI. In APs, serum DMKN levels were independently associated with MI (β = 0.56, p < 0.05).

Conclusions: We found a significant link between the profession of an airline pilot and changes in skin biophysical parameters. Further research into the interplay between serum DMKN levels and the risk of MM in APs is warranted.

航空公司飞行员的皮肤生物物理参数和血清皮质素水平:与办公室工作人员的比较研究。
导言:目的:比较40名男性飞行员与40名男性办公室工作人员(OW)对照组的五项皮肤生物物理参数,前者在年龄和工作年限(至少5年)方面与后者相匹配。考虑到去皮因子(DMKN)在皮肤屏障功能障碍和 MM 发病机制中的潜在作用,我们进一步分析了该分子的血清水平,并将其与测量的皮肤参数相关联:采用无创仪器对脸颊部位的角质层皮肤水合作用、经表皮失水(TEWL)、皮脂含量、红斑指数(EI)和黑色素指数(MI)进行量化。使用市售的酶联免疫吸附测定试剂盒测定了血清 DMKN 水平:结果:与 OW 相比,AP 的皮肤角质层水合水平下降,同时 TEWL 增加。不过,各组之间的皮脂含量没有明显差异。AP的MI明显高于OW,EI也是如此。在 APs 中,血清 DMKN 水平与 MI 独立相关(β = 0.56,p < 0.05):我们发现,飞行员职业与皮肤生物物理参数变化之间存在重要联系。我们认为有必要进一步研究血清 DMKN 水平与飞行员罹患心肌梗死风险之间的相互影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.60
自引率
7.10%
发文量
107
审稿时长
6-12 weeks
期刊介绍: Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii is a bimonthly aimed at allergologists and dermatologists.
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