Highlights of the Recent Patent Literature: Continuous Chemistry in the Pharmaceutical Industry

IF 3.1 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2024-01-26 DOI:10.1021/acs.oprd.3c00438

David L. Hughes*,

引用次数: 0

Abstract

Flow chemistry reactions and continuous separations have become established processing modalities in the pharmaceutical industry from early development to manufacturing. The current review highlights patents and patent applications from 2019 to 2023 wherein no accompanying journal article has been published, with a focus on examples that enable chemistries that are difficult or unsafe to scale in batch mode or provide significant process intensification.

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近期专利文献集锦：制药业中的连续化学

流动化学反应和连续分离已成为制药行业从早期开发到生产的成熟加工模式。本综述重点介绍了 2019 年至 2023 年期间未发表过相关期刊文章的专利和专利申请，重点关注那些能够实现批量模式下难以扩展或不安全的化学反应，或提供显著工艺强化的实例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.