Evaluation of Novel Dendrimer-Gold Complex Nanoparticles for Theranostic Application in Oncology.

Nanomedicine (London, England) Pub Date : 2024-03-01 Epub Date: 2024-01-26 DOI:10.2217/nnm-2023-0355

Nevena Milivojević, Mariana R Carvalho, David Caballero, Snežana Radisavljević, Marija Radoićić, Marko Živanović, Subhas C Kundu, Rui L Reis, Nenad Filipović, Joaquim M Oliveira

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引用次数: 0

Abstract

Aim: Despite some successful examples of therapeutic nanoparticles reaching clinical stages, there is still a significant need for novel formulations in order to improve the selectivity and efficacy of cancer treatment.

Methods: The authors developed two novel dendrimer-gold (Au) complex-based nanoparticles using two different synthesis routes: complexation method (formulation A) and precipitation method (formulation B). Using a biomimetic cancer-on-a-chip model, the authors evaluated the possible cytotoxicity and internalization by colorectal cancer cells of dendrimer-Au complex-based nanoparticles.

Results: The results showed promising capabilities of these nanoparticles for selectively targeting cancer cells and delivering drugs, particularly for the formulation A nanoparticles.

Conclusion: This work highlights the potential of dendrimer-Au complex-based nanoparticles as a new strategy to improve the targeting of anticancer drugs.

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评估新型树枝状聚合物-金复合物纳米粒子在肿瘤治疗中的应用。

目的：尽管有一些成功的治疗纳米粒子进入了临床阶段，但为了提高癌症治疗的选择性和疗效，仍然非常需要新型配方。研究方法作者采用两种不同的合成路线：络合法（配方 A）和沉淀法（配方 B），开发了两种新型树枝状聚合物-金（Au）复合物纳米粒子。作者利用仿生芯片癌症模型，评估了树枝状聚合物-金复合物纳米粒子可能具有的细胞毒性和被结直肠癌细胞内化的情况。结果显示结果表明，这些纳米颗粒具有选择性靶向癌细胞和递送药物的能力，尤其是 A 型纳米颗粒。结论这项工作凸显了基于树枝状聚合物-金复合物的纳米颗粒作为一种改善抗癌药物靶向性的新策略的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nanomedicine (London, England)

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