A Contemporary Review on the Critical Role of Nonsteroidal Anti-inflammatory Agents in Colorectal Cancer Therapy.

IF 2.6 4区医学 Q3 CHEMISTRY, MEDICINAL

Anti-cancer agents in medicinal chemistry Pub Date : 2024-01-01 DOI:10.2174/0118715206271583231206052403

Parisa Zia Sarabi, Mohammad Moradi, Malihe Bagheri, Mohammad Reza Khalili, Shahrzad Moradifard, Tannaz Jamialahmadi, Faezeh Ghasemi, Amirhossein Sahebkar

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引用次数: 0

Abstract

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are widely recognized as effective pain relievers and function by inhibiting the cyclooxygenase enzyme (COXs). Moreover, they have been found to participate in various cellular processes through different signaling pathways, such as WNT, MAPK, NF-κB, and PI3K/AKT/mTOR. This makes them potential candidates for chemoprevention of several malignancies, particularly colorectal cancer (CRC). However, the use of NSAIDs in cancer prevention and treatment is a complex issue due to their adverse effects and gastrointestinal toxicity. Therefore, it is crucial to explore combination therapies that can minimize side effects while maximizing synergistic effects with other agents and to evaluate the success rate of such approaches in both pre-clinical and clinical studies. In this review, we aim to provide an overview of the effects of NSAIDs in the prevention and treatment of CRC. We will focus on elucidating the possible mechanisms of action of these drugs, the signaling pathways involved in CRC, and the potential synergistic effects when combined with other therapeutic agents.

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非甾体类抗炎药物在结直肠癌治疗中的关键作用的当代回顾。

非甾体抗炎药（NSAIDs）是公认的有效止痛药，通过抑制环氧化酶（COXs）发挥作用。此外，它们还被发现通过不同的信号通路参与各种细胞过程，如 WNT、MAPK、NF-KB 和 PI3K/AKT/mTOR。这使它们成为化学预防多种恶性肿瘤，尤其是结直肠癌（CRC）的潜在候选药物。然而，由于非甾体抗炎药的不良反应和胃肠道毒性，在癌症预防和治疗中使用非甾体抗炎药是一个复杂的问题。因此，探索既能将副作用降到最低，又能与其他药物发挥最大协同作用的联合疗法，并在临床前和临床研究中评估此类方法的成功率至关重要。在本综述中，我们旨在概述非甾体抗炎药在预防和治疗 CRC 中的作用。我们将重点阐明这些药物可能的作用机制、参与 CRC 的信号通路以及与其他治疗药物联合使用时可能产生的协同效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anti-cancer agents in medicinal chemistry ONCOLOGY-CHEMISTRY, MEDICINAL

CiteScore

5.10

自引率

3.60%

发文量

323

审稿时长

4-8 weeks

期刊介绍： Formerly: Current Medicinal Chemistry - Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.