Evaluation of growth hormone deficiency in women with unexplained infertility

IF 1.6 4区医学 Q4 CELL BIOLOGY

Growth Hormone & Igf Research Pub Date : 2024-02-01 DOI:10.1016/j.ghir.2024.101571

Mehmet Serif Ortac , Aysa Hacioglu , Semih Zeki Uludag , Zuleyha Karaca , Kursad Unluhizarci , Fahrettin Kelestimur , Fatih Tanriverdi

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Abstract

Purpose

Growth hormone (GH) has been recognized to play a regulatory role in female reproduction. It has been reported that infertile GH deficient patients regained fertility after GH replacement. The frequency of GH deficiency is not established in patients diagnosed with unexplained infertility. Here, we aim to present the prevalence of GH deficieny in this patient group.

Methods

We included patients diagnosed with unexplained infertility throughout 18 months. Insulin tolerance test (ITT) and glucagon stimulation tests (GST) were performed and insufficient response to both tests was required for the diagnosis of GH deficiency.

Results

Twenty-five patients were included in the study, the mean age was 27.4 ± 4.5 years and the median duration of infertility was 60 months (min:14, max:120). Two patients were GH deficient according to GST and 14 to ITT. Two patients (8%) showed lack of response on both tests and were diagnosed with GH deficiency.

Conclusion

The rate of GH deficiency among women with unexplained infertility was 8% in this preliminary study. There is need for further studies with larger patient groups to verify the results.

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评估不明原因不孕妇女的生长激素缺乏症

目的生长激素（GH）被认为在女性生殖过程中发挥着调节作用。有报道称，缺乏 GH 的不孕症患者在补充 GH 后可恢复生育能力。在诊断为不明原因不孕症的患者中，GH缺乏症的发病率尚未确定。在此，我们旨在介绍 GH 缺乏症在这一患者群体中的发病率。结果25名患者被纳入研究，平均年龄为（27.4±4.5）岁，中位不孕时间为60个月（最小14个月，最大120个月）。根据 GST，2 名患者缺乏 GH，根据 ITT，14 名患者缺乏 GH。结论在这项初步研究中，不明原因不孕症妇女中的 GH 缺乏率为 8%。需要对更大的患者群体进行进一步研究，以验证研究结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Growth Hormone & Igf Research 医学-内分泌学与代谢

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

57 days

期刊介绍： Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.