Indy van der Berg, Sabine Schootemeijer, Karin Overbeek, Bastiaan R. Bloem, Nienke M. de Vries
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引用次数: 0
Abstract
Several dietary patterns and nutritional supplements have been linked to the development, progression, and symptomatic treatment of Parkinson’s disease (PD). Most of the evidence, at this point, is preliminary and based largely on observational studies. Interventional studies are scarce, so the evidence on effectiveness remains inconclusive. Dietary interventions could, analogous to exercise, potentially have a beneficial effect on disease symptoms as well as on the progression of the disease and should therefore be researched in high quality studies. Further work is also needed to study whether dietary interventions, when applied to an at-risk population, have any potential to postpone the onset of manifest PD. In this paper, we summarize all ongoing clinical trials on dietary interventions in PD. We found 10 ongoing studies, all aimed at a different intervention. These studies are mostly exploratory in nature or represent phase I or phase II trials focusing on safety, biological responses, and symptomatic effects. Taken together, we conclude that research on dietary interventions in persons with PD is still in its early days. The results of the various ongoing trials are expected to generate new hypotheses and will help to shape the agenda for future research on this important topic.
摘要几种饮食模式和营养补充剂与帕金森病（PD）的发生、发展和对症治疗有关。目前，大多数证据都是初步的，主要基于观察性研究。干预性研究很少，因此有关有效性的证据仍不确定。与运动类似，饮食干预可能会对疾病症状和疾病进展产生有益影响，因此应在高质量的研究中加以探讨。此外，还需要进一步研究饮食干预在应用于高危人群时，是否有可能推迟明显的帕金森病的发病时间。在本文中，我们总结了所有正在进行的针对帕金森病的饮食干预临床试验。我们发现了 10 项正在进行的研究，所有研究都针对不同的干预措施。这些研究大多是探索性的，或者是 I 期或 II 期试验，重点关注安全性、生物反应和症状效应。综上所述，我们得出结论，针对帕金森病患者的饮食干预研究仍处于早期阶段。正在进行的各种试验的结果有望产生新的假设，并将有助于为这一重要课题的未来研究制定议程。
期刊介绍：
The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.
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