{"title":"Phytochemical, nutraceutical and oxidative stress modulation activities of Solanum villosum Mill. leaf and berry extracts","authors":"","doi":"10.1007/s12210-023-01212-x","DOIUrl":null,"url":null,"abstract":"<h3>Abstract</h3> <p>The present work depicted the pharmacological and nutritional importance of <em>Solanum villosum</em> Mill. based on its traditional value. It is an ethnomedicinal plant of the family Solanaceae used to treat edema and sore eyes, apart from its use as salad and fruit. Leaves and berries of <em>Solanum villosum</em> were explored for the bioactive compounds, antioxidant activity and nutritional potential. Plant extract of both parts i.e., leaves and berries were prepared in methanol and chloroform solvent, then subjected to analysis. Alkaloids, flavonoids, phenols, saponins, and tannins were quantified as major phytochemicals. Antioxidant activity was tested by DPPH radical scavenging, Phosphomolybdate and reducing power assay. Brine shrimp lethality assay was employed to study cytotoxic activity of extracts. Assessment of nutritional value was done by proximate analysis. Alkaloids and saponins were present in significant quantities i.e., 7.6 mg g<sup>−1</sup>, 3.48 mg g<sup>−1</sup>, 5.67 mg g<sup>−1</sup>, and 1.98 mg g<sup>−1</sup> in leaves and berries respectively. Methanol extracts exhibited noticeable antioxidant activity, as compared to chloroform extracts. Higher antioxidant activity of leaves was reported as compared to berries with IC<sub>50</sub> values of 196.86 µg mL<sup>−1</sup> by Phosphomolybdate assay. Methanol extract of leaves demonstrated promising cytotoxic activity with LD<sub>50</sub> value of 74.44 μg mL<sup>−1</sup>. Results for nutritional analysis indicated presence of carbohydrates, proteins, and crude fiber in both extracts, while protein content was higher in berries. Results of the study suggest that the plant can be utilized as a source of balanced nutraceutical products having benefits of food and medicine.</p>","PeriodicalId":54501,"journal":{"name":"Rendiconti Lincei-Scienze Fisiche E Naturali","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rendiconti Lincei-Scienze Fisiche E Naturali","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1007/s12210-023-01212-x","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
The present work depicted the pharmacological and nutritional importance of Solanum villosum Mill. based on its traditional value. It is an ethnomedicinal plant of the family Solanaceae used to treat edema and sore eyes, apart from its use as salad and fruit. Leaves and berries of Solanum villosum were explored for the bioactive compounds, antioxidant activity and nutritional potential. Plant extract of both parts i.e., leaves and berries were prepared in methanol and chloroform solvent, then subjected to analysis. Alkaloids, flavonoids, phenols, saponins, and tannins were quantified as major phytochemicals. Antioxidant activity was tested by DPPH radical scavenging, Phosphomolybdate and reducing power assay. Brine shrimp lethality assay was employed to study cytotoxic activity of extracts. Assessment of nutritional value was done by proximate analysis. Alkaloids and saponins were present in significant quantities i.e., 7.6 mg g−1, 3.48 mg g−1, 5.67 mg g−1, and 1.98 mg g−1 in leaves and berries respectively. Methanol extracts exhibited noticeable antioxidant activity, as compared to chloroform extracts. Higher antioxidant activity of leaves was reported as compared to berries with IC50 values of 196.86 µg mL−1 by Phosphomolybdate assay. Methanol extract of leaves demonstrated promising cytotoxic activity with LD50 value of 74.44 μg mL−1. Results for nutritional analysis indicated presence of carbohydrates, proteins, and crude fiber in both extracts, while protein content was higher in berries. Results of the study suggest that the plant can be utilized as a source of balanced nutraceutical products having benefits of food and medicine.
期刊介绍：
Rendiconti is the interdisciplinary scientific journal of the Accademia dei Lincei, the Italian National Academy, situated in Rome, which publishes original articles in the fi elds of geosciences, envi ronmental sciences, and biological and biomedi cal sciences. Particular interest is accorded to papers dealing with modern trends in the natural sciences, with interdisciplinary relationships and with the roots and historical development of these disciplines.
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