Association study of a single nucleotide polymorphism in the hypoxia response element of the macrophage migration inhibitory factor gene promoter with suicide completers in the Japanese population.

IF 2 Q3 NEUROSCIENCES
Neuropsychopharmacology Reports Pub Date : 2024-03-01 Epub Date: 2024-01-24 DOI:10.1002/npr2.12410
Toshiyuki Shirai, Satoshi Okazaki, Takaki Tanifuji, Ikuo Otsuka, Masao Miyachi, Shohei Okada, Ryota Shindo, Tadasu Horai, Kentaro Mouri, Motonori Takahashi, Takeshi Kondo, Yasuhiro Ueno, Akitoyo Hishimoto
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Abstract

Background: More than 800 000 people die by suicide annually. The heritability of suicide is 30%-50%. We focused on the hypoxia response element (HRE), which promotes the expression of macrophage migration inhibitory factor (MIF) via the hypoxia-inducible factor (HIF) pathway, important in neurogenesis and neuroprotection. We examined a genetic polymorphism of rs17004038, a single-nucleotide polymorphism (SNP), in suicide completers and controls.

Methods: The study population included 1336 suicide completers and 814 unrelated healthy controls. All participants were Japanese. We obtained peripheral blood, extracted DNA, and genotyped the patients for SNP rs17004038 (C > A).

Results: No significant differences were observed between the two groups in either the allele or genotype analyses. Subgroup analyses by sex, age (<40 or ≥40), and suicide method (violent or nonviolent suicide) were performed with similar results.

Conclusion: No association was observed between SNP rs17004038 and suicide completion. Although it is challenging to collect a large number of samples from suicide completers, further MIF-related genetic studies, including those of rs17004038, are necessary with larger sample sizes.

巨噬细胞迁移抑制因子基因启动子缺氧反应元件中的单核苷酸多态性与日本人群自杀完成者的关联研究。
背景:每年有 80 多万人死于自杀。自杀的遗传率为 30%-50%。我们重点研究了缺氧反应元件(HRE),它通过缺氧诱导因子(HIF)途径促进巨噬细胞迁移抑制因子(MIF)的表达,在神经发生和神经保护中具有重要作用。我们研究了单核苷酸多态性(SNP)rs17004038在自杀完成者和对照组中的遗传多态性:研究对象包括 1336 名自杀者和 814 名无关的健康对照者。所有参与者均为日本人。我们采集了患者的外周血,提取了 DNA,并对 SNP rs17004038(C > A)进行了基因分型:结果:在等位基因和基因型分析中,两组之间均未发现明显差异。按性别、年龄进行的亚组分析(结论:SNP rs17004038 的基因型与患者的性别、年龄无明显关联:未观察到 SNP rs17004038 与自杀完成之间存在关联。尽管从自杀完成者中收集大量样本具有挑战性,但仍有必要进行更多样本量的进一步 MIF 相关基因研究,包括 rs17004038 的研究。
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来源期刊
Neuropsychopharmacology Reports
Neuropsychopharmacology Reports Psychology-Clinical Psychology
CiteScore
3.60
自引率
4.00%
发文量
75
审稿时长
14 weeks
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