Sex-specific differences in a large cohort of Brazilian incident dialysis patients over 12 years: A retrospective study.

IF 1.4 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Fabiana Baggio Nerbass, Helbert do Nascimento Lima, Jocemir Ronaldo Lugon, Ricardo Sesso
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引用次数: 0

Abstract

Objective: Sex-specific differences in the epidemiology of chronic kidney disease, such as higher prevalence of women on pre-dialysis and men on chronic dialysis treatment, have been reported worldwide. In this regard, data from non-high-income countries are scarce. We aimed to compare the demographic, clinical, and dialysis characteristics of incident dialysis patients, both men and women, in a large cohort of Brazilian patients over a 12-year period.

Methods: This was a multicentric retrospective cohort study coordinated by the Brazilian Society of Nephrology. The study included all adult incident dialysis patients in the Brazilian Dialysis Registry from January 2011 to December 2022. The variables studied encompassed age, skin color, education, CKD etiology, predialysis nephrologist care, dialysis characteristics, and geographic region. Additionally, the sample was analyzed for each of the three 4-year periods over the 12 years of data collection.

Results: A total of 24,632 incident dialysis patients were included. Men were 59.1% of the dialysis population, remaining stable over the three 4-year periods. Besides other differences, women started dialysis younger (58.5 ± 16.2 years vs 59.5 ± 14.4 years; p < 0.001), had a lower educational level (less than 8 years at school: 54% vs 44%; p < 0.001), received more predialysis nephrologist care (46.2% vs 44.2%; p = 0.04), and had a higher prevalence of peritoneal dialysis (4.4% vs 3.5%; p = 0.03).

Conclusion: We consistently observed a higher prevalence of men on dialysis and differences in demographic, clinical, and dialysis characteristics. The underlying reasons for these sex differences still necessitate further clarification.

一项回顾性研究:12 年来巴西大量透析患者的性别差异:回顾性研究
目的:世界各地都有关于慢性肾脏病流行病学中性别差异的报道,例如女性接受透析前治疗和男性接受慢性透析治疗的比例较高。在这方面,来自非高收入国家的数据很少。我们的目的是比较一个大型巴西患者队列中 12 年间发生透析的男性和女性患者的人口统计学、临床和透析特征:这是一项由巴西肾脏病学会协调的多中心回顾性队列研究。研究对象包括 2011 年 1 月至 2022 年 12 月期间巴西透析登记处的所有成年透析患者。研究变量包括年龄、肤色、教育程度、慢性肾脏病病因、透析前肾科医生护理、透析特征和地理区域。此外,在数据收集的 12 年中,对三个 4 年期的样本进行了分析:结果:共纳入了 24,632 例透析患者。男性占透析人群的 59.1%,在三个四年期内保持稳定。除其他差异外,女性开始透析的年龄更小(58.5 ± 16.2 岁 vs 59.5 ± 14.4 岁;p p = 0.04),腹膜透析率更高(4.4% vs 3.5%;p = 0.03):我们持续观察到男性接受透析的比例较高,并且在人口统计学、临床和透析特征方面存在差异。这些性别差异的根本原因仍需进一步澄清。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Artificial Organs
International Journal of Artificial Organs 医学-工程:生物医学
CiteScore
3.40
自引率
5.90%
发文量
92
审稿时长
3 months
期刊介绍: The International Journal of Artificial Organs (IJAO) publishes peer-reviewed research and clinical, experimental and theoretical, contributions to the field of artificial, bioartificial and tissue-engineered organs. The mission of the IJAO is to foster the development and optimization of artificial, bioartificial and tissue-engineered organs, for implantation or use in procedures, to treat functional deficits of all human tissues and organs.
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