Hyperuricemia: An Intriguing Connection to Metabolic Syndrome, Diabetes, Kidney Disease, and Hypertension.

IF 3.9 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Current Hypertension Reports Pub Date : 2024-06-01 Epub Date: 2024-01-25 DOI:10.1007/s11906-024-01295-3
Ramzi Vareldzis, Annalisa Perez, Efrain Reisin
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引用次数: 0

Abstract

Purpose of the review: Our review explores the epidemiology, physiology, and clinical data surrounding the connection between hyperuricemia and metabolic syndrome, chronic kidney disease, and hypertension.

Recent findings: Compelling physiologic mechanisms have been proposed to explain a causal relationship between hyperuricemia and metabolic syndrome, chronic kidney disease, and hypertension but clinical studies have given mixed results in terms of whether intervening with hyperuricemia using urate-lowering therapy has any beneficial effects for patients with these conditions. Despite the large amount of research already put into this topic, more randomized placebo-controlled trials are needed to more firmly establish whether a cause-effect relationship exists and whether lowering uric acid levels in patients with these conditions is beneficial.

高尿酸血症:高尿酸血症:与代谢综合征、糖尿病、肾病和高血压之间的有趣联系。
综述的目的:我们的综述探讨了围绕高尿酸血症与代谢综合征、慢性肾病和高血压之间联系的流行病学、生理学和临床数据:人们已经提出了令人信服的生理机制来解释高尿酸血症与代谢综合征、慢性肾脏病和高血压之间的因果关系,但对于使用降尿酸疗法干预高尿酸血症是否会对这些疾病的患者产生任何有益的影响,临床研究的结果却不尽相同。尽管已经对这一课题进行了大量研究,但还需要更多的随机安慰剂对照试验,以更明确地确定是否存在因果关系,以及降低这些疾病患者的尿酸水平是否有益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Hypertension Reports
Current Hypertension Reports 医学-外周血管病
CiteScore
10.50
自引率
0.00%
发文量
65
审稿时长
6-12 weeks
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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