Role of Interleukin-17 family cytokines in disease severity of patients with knee osteoarthritis.

IF 2 4区医学 Q3 RHEUMATOLOGY

Advances in Rheumatology Pub Date : 2024-01-24 DOI:10.1186/s42358-024-00351-5

Zahra Kamiab, Hossein Khorramdelazad, Mehdi Kafi, Abdollah Jafarzadeh, Vahid Mohammadi-Shahrokhi, Zahra Bagheri-Hosseinabadi, Pooya Saeed Askari, Mitra Abbasifard

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引用次数: 0

Abstract

Background: Interleukin-17 (IL-17) family plays a role in the pathogenesis of knee osteoarthritis (KOA) by contributing to the inflammatory and destructive processes in the affected joint. This study aimed to measure levels of IL-17 A and IL-25 (IL-17E) in serum of KOA patients and determine their roles in the disease severity of patients.

Methods: In this, 34 patients with KOA and 30 age and sex-matched healthy subjects (HS) were enrolled. Patients were categorized based on their Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analog Scale (VAS), and Body Mass Index (BMI) scores. The enzyme-linked immunosorbent assay (ELISA) technique was employed to measure serum levels of IL-17 A and IL-25.

Results: Level of IL-25 was significantly higher (P < 0.0001) in the KOA subjects than HS. IL-17 A level was significantly higher in KOA cases with WOMAC < 40 (P < 0.0001) in comparison to HS. IL-25 level was significantly higher in the KOA cases with WOMAC < 40 (P < 0.0001) and with WOMAC ≥ 40 (P < 0.0001) compared to HS. IL-17 A concentration was significantly higher in the KOA cases with VAS < 5 (P < 0.0001) compared to HS. IL-25 level was significantly higher in the KOA cases with VAS < 5 (P < 0.0001) and with VAS ≥ 5 (P < 0.0001) in comparison to HS. KOA patients with BMI ≥ 30 had significantly higher IL-17 A and IL-25 concentration in comparison to HS.

Conclusions: The serum level of IL-25 in KOA patients is increased probably due to negative controlling feedback on inflammatory responses, which can be associated with obesity and disease activity.

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白细胞介素-17 家族细胞因子在膝关节骨关节炎患者病情严重程度中的作用。

背景：白细胞介素-17（IL-17）家族在膝关节骨性关节炎（KOA）的发病机制中扮演着重要角色，因为它能促进受影响关节的炎症和破坏过程。本研究旨在检测 KOA 患者血清中 IL-17 A 和 IL-25 (IL-17E) 的水平，并确定它们在患者疾病严重程度中的作用：本研究共招募了 34 名 KOA 患者和 30 名年龄与性别匹配的健康受试者（HS）。根据患者的西安大略和麦克马斯特大学骨关节炎指数（WOMAC）、视觉模拟量表（VAS）和体重指数（BMI）评分对患者进行分类。采用酶联免疫吸附试验（ELISA）技术测定血清中 IL-17 A 和 IL-25 的水平：结果：IL-25 的水平明显较高（PKOA患者血清中IL-25水平升高可能是由于炎症反应的负向控制反馈，这可能与肥胖和疾病活动有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Rheumatology Medicine-Rheumatology

CiteScore

4.00

自引率

4.30%

发文量

审稿时长

53 weeks

期刊介绍： Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication. Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.