Elevation of free triiodothyronine (fT3) levels by Plasmodium falciparum independent of thyroid stimulating hormone (TSH) in children with uncomplicated malaria

IF 2.6 4区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Journal of Clinical Laboratory Analysis Pub Date : 2024-01-25 DOI:10.1002/jcla.25013

Henrietta Kwansa-Bentum, Enoch Aninagyei, David Adedia, Nii Korley Kortei, Adjoa Boakye Agyemang, Clement Okraku Tettey

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Abstract

Background

Malaria parasites have a devastating effect on the infected host. However, there is a paucity of data on the effect of Plasmodium falciparum on thyroid hormones.

Methods

This case–control study (1:1) involved children <16 years of age with uncomplicated malaria. Hematological parameters were determined using the URIT-5380 hematology analyzer (China). Later, levels of thyroid hormones, namely free triiodothyronine (fT3), free tetraiodothyronine (fT4), and thyroid-stimulating hormone (TSH), were determined using human ELISA kits (DiaSino ELISA kit, Zhengzhou, China).

Results

Ninety children with malaria and ninety matched control group were studied. Overall, compared to the control group, lower TSH (3.43 ± 1.25 vs. 3.84 ± 1.34, p = 0.035) and elevated levels of fT3 levels (5.85 ± 1.79 vs. 3.89 ± 1.19, p < 0.001) were observed in patients with malaria. However, fT4 levels were comparable between cases and control group (16.37 ± 2.81 vs 17.06 ± 3.5, p = 0.150). Free T3 levels were significantly higher in children <10 years (p < 0.001) and higher among male children with malaria (p < 0.001). Overall, there was a significant positive relationship between parasite counts and fT3 (R = 0.95, p < 0.001). Furthermore, body temperature was positively correlated with fT3 (R = 0.97, p < 0.001).

Conclusions

Isolated fT3 thyrotoxicosis was observed in falciparum malaria, especially in children <10 years and male malaria patients, independent of TSH. This observation could explain the severity of malaria in children.

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无并发症疟疾患儿体内游离三碘甲状腺原氨酸（fT3）水平受恶性疟原虫影响而升高，与促甲状腺激素（TSH）无关。

背景：疟疾寄生虫会对受感染的宿主产生破坏性影响。然而，有关恶性疟原虫对甲状腺激素影响的数据却很少：这项病例对照研究（1:1）涉及儿童：研究对象包括90名疟疾患儿和90名匹配的对照组儿童。总体而言，与对照组相比，儿童甲状腺激素水平较低（3.43 ± 1.25 vs. 3.84 ± 1.34，p = 0.035），而 fT3 水平较高（5.85 ± 1.79 vs. 3.89 ± 1.19，p 结论：与对照组相比，儿童甲状腺激素水平较高（5.85 ± 1.79 vs. 3.89 ± 1.19，p = 0.035）：在恶性疟原虫疟疾中观察到了孤立的 fT3 甲状腺毒症，尤其是在儿童中

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Laboratory Analysis 医学-医学实验技术

CiteScore

5.60

自引率

7.40%

发文量

584

审稿时长

6-12 weeks

期刊介绍： Journal of Clinical Laboratory Analysis publishes original articles on newly developing modes of technology and laboratory assays, with emphasis on their application in current and future clinical laboratory testing. This includes reports from the following fields: immunochemistry and toxicology, hematology and hematopathology, immunopathology, molecular diagnostics, microbiology, genetic testing, immunohematology, and clinical chemistry.