Current Advances and Future Perspectives on Mesenchymal Stem Cell-Derived Extracellular Vesicles in Alzheimer's Disease.

IF 7 2区医学 Q1 GERIATRICS & GERONTOLOGY

Aging and Disease Pub Date : 2024-10-01 DOI:10.14336/AD.2023.1206

Wenjing Zhang, Russell Uyemura, Kun Zhong, Rui Guo, Li Zhong

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引用次数: 0

Abstract

The incidence of Alzheimer's disease (AD) has been increasing in recent years as the world's population ages, which poses a significant challenge to public health. Due to the complexity of pathogenesis of AD, currently there is no effective treatment for it. In recent years, cell and gene therapy has attracted widespread attention in the treatment of neurodegenerative diseases. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) represent a novel cell-free therapy with numerous advantages over cell-based therapies owing to their low immunogenicity and high safety profile. We summarize recent progress in the application of EVs for treating AD and the specific mechanisms and outline the underlying mechanisms. We also explore various methods for optimizing the function of MSC-EVs, including gene editing, modifying stem cell culture conditions and peptide modification. In addition, we discuss the therapeutic potentials of MSC-EVs, as well as the obstacles that currently impede their clinical utilization.

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间充质干细胞衍生的细胞外小泡在阿尔茨海默病中的研究进展和未来展望。

近年来，随着全球人口老龄化的加剧，阿尔茨海默病（AD）的发病率也在不断上升，这给公共卫生带来了巨大挑战。由于阿尔茨海默病发病机制复杂，目前尚无有效的治疗方法。近年来，细胞和基因疗法在治疗神经退行性疾病方面受到广泛关注。间充质干细胞衍生的细胞外囊泡（MSC-EVs）是一种新型的无细胞疗法，由于其免疫原性低、安全性高，与基于细胞的疗法相比具有诸多优势。我们总结了应用EVs治疗AD的最新进展和具体机制，并概述了其基本机制。我们还探讨了优化间充质干细胞-EVs功能的各种方法，包括基因编辑、改变干细胞培养条件和多肽修饰。此外，我们还讨论了间充质干细胞-EVs的治疗潜力，以及目前阻碍其临床应用的障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging and Disease GERIATRICS & GERONTOLOGY-

CiteScore

14.60

自引率

2.70%

发文量

138

审稿时长

10 weeks

期刊介绍： Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.