Gastro Retentive Drug Delivery System

Abstract

In recent years, gastro retentive drug delivery systems have gained research interest in the field of oral drug delivery. The purpose of reviewing gastro-retentive drug delivery systems (GRDDS) is to accumulate the current literature with a special emphasis on several gastro-retentive approaches that have recently become important methodologies in the field of site-specific orally administered sustained or controlled-release drug delivery. Gastro-retentive drug delivery systems can be used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve the bioavailability of a particular drug substance. Conventional oral dosage forms pose low bioavailability problems. Several efforts have been made to extend the drug delivery system to reduce the frequency of dose administration. GRDDS not only prolongs dosing intervals but also increases patient compliance beyond the level of existing controlled-release dosage forms.