Successful Control of Some Challenging Cases in Late Adult and Elderly Onset Atopic Dermatitis with Dupilumab Injection in Kuwaiti Patients: A Prospective Pilot Study

Abstract

Atopic Dermatitis is severely itchy skin disease with chronic prolonged course and relapsing flares, which was considered mainly infantile or childhood in onset for a long time. Atopic Dermatitis is not any more a pediatric dermatosis, an emerging new entity in adult and elderly patients became more and more identified. An elderly onset of Atopic Dermatitis is mainly due to aging process. There are various causes that reduce skin function, especially senile xerosis of skin in these age group. Dryness itself makes skin as weak as a protective barrier in elderly, in addition to pathophysiological changes in aging human skin. All previous factors might trigger Atopic Dermatitis pictures over elderly patient. Atopic Dermatitis in elderly might does not look so bad as morphological reflection on skin, but intolerable pruritus’ accompanied this skin condition is more concerned. Dupilumab as well-known safe and effective controlling therapy for atopic dermatitis, given a light at end of tunnel specially for severe pruritus’ which affect badly life quality in these poor patients. This article represents a close review of etiopathogenesis of late adult and elderly onset atopic dermatitis. Also, we represent 10 cases of confirmed late adult and elderly Atopic Dermatitis who have a proper control on Dupilumab injection safely without any drawbacks on patients.