Trigeminal Postherpetic Neuralgia: From Pathophysiology to Treatment.

IF 3.2 2区医学 Q2 CLINICAL NEUROLOGY

Current Pain and Headache Reports Pub Date : 2024-04-01 Epub Date: 2024-01-23 DOI:10.1007/s11916-023-01209-z

Christy S Niemeyer, Michael Harlander-Locke, Andrew N Bubak, Rachael Rzasa-Lynn, Marius Birlea

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引用次数: 0

Abstract

Purpose of review: Trigeminal postherpetic neuralgia (TG-PHN) is a neuropathic pain condition complicating herpes zoster (HZ) attributed to the trigeminal nerve. It poses significant challenges due to its persistent and debilitating nature. This review explores the clinical characteristics of TG-PHN, analyzes its pathophysiological underpinnings, and addresses existent and potential therapies.

Recent findings: TG-PHN is one of the most common and complex PHN locations. It has distinguishing clinical and pathophysiological characteristics, starting with viral triggered injuries to the trigeminal ganglion (TG) and peripheral tissue and involving the ascending and descending brain modulation pathways. Current therapies include vaccines, oral and topical medications, and interventional approaches, like nerve blocks and neurostimulation. This review covers TG-PHN's clinical and physiological components, treatment options, and potential future targets for improved management. By exploring the complexities of this condition, we aim to contribute to developing more effective and targeted therapies for patients suffering from trigeminal PHN.

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三叉神经带后遗神经痛：从病理生理学到治疗。

审查目的：三叉神经带状疱疹后遗神经痛（TG-PHN）是带状疱疹（HZ）并发三叉神经的一种神经病理性疼痛。由于其顽固性和令人衰弱的性质，它带来了巨大的挑战。本综述探讨了 TG-PHN 的临床特征，分析了其病理生理基础，并探讨了现有和潜在的治疗方法：TG-PHN 是最常见、最复杂的 PHN 病变之一。它具有显著的临床和病理生理学特征，起因于病毒引发的三叉神经节（TG）和外周组织损伤，并涉及上升和下降的大脑调节通路。目前的疗法包括疫苗、口服和外用药物，以及神经阻滞和神经刺激等介入方法。本综述涵盖了 TG-PHN 的临床和生理成分、治疗方案以及未来改善管理的潜在目标。通过探讨这种疾病的复杂性，我们希望为三叉神经 PHN 患者开发更有效、更有针对性的疗法做出贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Pain and Headache Reports CLINICAL NEUROLOGY-

CiteScore

6.10

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published clinical findings regarding the diagnosis, treatment, and management of pain and headache. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of pain and headache. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anesthetic techniques in pain management, cluster headache, neuropathic pain, and migraine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.