The Role of Cytokines in Activation of Tumour-promoting Pathways and Emergence of Cancer Drug Resistance.

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2024-01-01 DOI:10.2174/0115680266284527240118041129

Ekta Shirbhate, Vaibhav Singh, Rakesh Kore, Subham Vishwakarma, Ravichandran Veerasamy, Amit K Tiwari, Harish Rajak

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Abstract

Scientists are constantly researching and launching potential chemotherapeutic agents as an irreplaceable weapon to fight the battle against cancer. Despite remarkable advancement over the past several decades to wipe out cancer through early diagnosis, proper prevention, and timely treatment, cancer is not ready to give up and leave the battleground. It continuously tries to find some other way to give a tough fight for its survival, either by escaping from the effect of chemotherapeutic drugs or utilising its own chemical messengers like cytokines to ensure resistance. Cytokines play a significant role in cancer cell growth and progression, and the present article highlights their substantial contribution to mechanisms of resistance toward therapeutic drugs. Multiple clinical studies have even described the importance of specific cytokines released from cancer cells as well as stromal cells in conferring resistance. Herein, we discuss the different mechanism behind drug resistance and the crosstalk between tumor development and cytokines release and their contribution to showing resistance towards chemotherapeutics. As a part of this review, different approaches to cytokines profile have been identified and employed to successfully target new evolving mechanisms of resistance and their possible treatment options.

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细胞因子在激活肿瘤促进途径和癌症抗药性出现中的作用

科学家们不断研究和推出潜在的化疗药物，将其作为抗击癌症不可替代的武器。尽管过去几十年来，通过早期诊断、适当预防和及时治疗消灭癌症的工作取得了显著进展，但癌症并不准备放弃和离开战场。它不断试图寻找其他方法来为自己的生存打一场硬仗，要么逃避化疗药物的作用，要么利用自身的化学信使（如细胞因子）来确保抵抗力。细胞因子在癌细胞的生长和发展过程中扮演着重要角色，本文将重点介绍细胞因子在抗药性机制中的重要作用。多项临床研究甚至描述了癌细胞和基质细胞释放的特定细胞因子在产生抗药性方面的重要性。在此，我们将讨论耐药性背后的不同机制，以及肿瘤发生和细胞因子释放之间的相互影响及其对化疗药物产生耐药性的贡献。作为本综述的一部分，我们已经确定并采用了不同的细胞因子分析方法，以成功针对不断演变的新抗药性机制及其可能的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.