Periodontal disease in down syndrome: Predisposing factors and potential non-surgical therapeutic approaches

IF 2.6 4区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Journal of Clinical Laboratory Analysis Pub Date : 2024-01-22 DOI:10.1002/jcla.25002

Mahdie Ghaffarpour, Morteza Karami-Zarandi, Hossein Ali Rahdar, Seifu Gizaw Feyisa, Elahe Taki

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Abstract

Background

Periodontal diseases (PDs) have been documented to be significantly more prevalent and severe in patients with Down syndrome (DS). Different immunological and microbiological factors contributed to predisposing these patients to progressive and recurrent PDs.

Aim

The aim of this review was to investigate the altered immunological responses and oral microbiota disorders as well as focus on adjunctive non-surgical methods for the treatment of PDs and its applicability in patients with DS.

Material and Methods

A literature review was conducted addressing the following topics: (1) the altered immunological responses, (2) orofacial disorders related to DS patients, (3) oral microbiota changing, and (4) adjunctive non-surgical treatment and its efficacy in patients with DS.

Results

Due to the early onset of PDs in children with DS, the need for prompt and effective treatment in these patients is essential.

Discussion and Conclusion

So, investigating underlying factors may open a new window to better understand the pathology of PDs in DS people and thus, find better strategies for treatment in such group. Although non-surgical treatments such as photodynamic therapy and probiotic consumption represented acceptable outcomes in different examined patients without DS, data about the application of these convenience and no need for local anesthesia methods in patients with DS is limited.

Abstract Image

查看原文本刊更多论文

唐氏综合征的牙周病：诱发因素和潜在的非手术治疗方法。

背景：有资料显示，牙周疾病（PDs）在唐氏综合征（DS）患者中的发病率和严重程度明显更高。目的：本综述旨在研究免疫反应的改变和口腔微生物群紊乱，并重点关注治疗牙周疾病的非手术辅助方法及其在唐氏综合征患者中的适用性：针对以下主题进行了文献综述：(1）免疫反应的改变；（2）与DS患者相关的口腔疾病；（3）口腔微生物群的变化；（4）辅助性非手术治疗及其对DS患者的疗效：由于DS患儿的口腔颌面部疾病发病较早，因此必须对这些患者进行及时有效的治疗：因此，对潜在因素的研究可能会打开一扇新窗口，让我们更好地了解DS患者PDs的病理，从而找到更好的治疗策略。虽然光动力疗法和服用益生菌等非手术治疗方法在不同的非DS患者中取得了可接受的结果，但在DS患者中应用这些方便且无需局部麻醉方法的数据却很有限。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Laboratory Analysis 医学-医学实验技术

CiteScore

5.60

自引率

7.40%

发文量

584

审稿时长

6-12 weeks

期刊介绍： Journal of Clinical Laboratory Analysis publishes original articles on newly developing modes of technology and laboratory assays, with emphasis on their application in current and future clinical laboratory testing. This includes reports from the following fields: immunochemistry and toxicology, hematology and hematopathology, immunopathology, molecular diagnostics, microbiology, genetic testing, immunohematology, and clinical chemistry.