Synthesis and Antiviral Activity of Copolymers of Hydroxycinnamic Acid with N-Vinylamides

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Doklady Chemistry Pub Date : 2024-01-20 DOI:10.1134/S0012500823600992

N. A. Nesterova, A. A. Shtro, E. F. Panarin

引用次数: 0

Abstract

Radical copolymerization of coumarin with N-vinylamides (N‑vinylpyrrolidone, N-methyl-N-vinylacetamide, N-vinylformamide) has been used to prepare copolymers of various composition with variable molecular weights. Subsequent reactions in their polymer chains affords water-soluble copolymers of salts of hydroxycinnamic acid and its hydrazides. The synthesized copolymers of hydroxycinnamic acid salts and hydrazides with N-vinylamides have low cytotoxicity and demonstrate the pronounced antiviral activity against human respiratory syncytial virus (strain A2).

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羟基肉桂酸与 N-乙烯基酰胺共聚物的合成及抗病毒活性

摘要香豆素与 N-乙烯基酰胺（N-乙烯基吡咯烷酮、N-甲基-N-乙烯基乙酰胺、N-乙烯基甲酰胺）的 Radical 共聚已被用于制备分子量可变的各种成分的共聚物。随后在聚合物链中进行反应，可得到羟基肉桂酸及其酰肼盐类的水溶性共聚物。合成的羟基肉桂酸盐和酰肼与 N-乙烯酰胺的共聚物具有较低的细胞毒性，对人类呼吸道合胞病毒（A2 株）具有明显的抗病毒活性。

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来源期刊

Doklady Chemistry 化学-化学综合

CiteScore

1.20

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Chemistry is a journal that publishes new research in chemistry and chemical engineering of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.