Therapeutic potential of adiponectin in prediabetes: strategies, challenges, and future directions.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-01-18 eCollection Date: 2024-01-01 DOI:10.1177/20420188231222371

Mona Mohamed Ibrahim Abdalla

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Abstract

Adiponectin, an adipose-derived hormone, plays a pivotal role in glucose regulation and lipid metabolism, with a decrease in circulating adiponectin levels being linked to insulin resistance and prediabetes. This review examines the therapeutic potential of adiponectin in managing prediabetes, elucidating on multiple aspects including its role in glucose and lipid metabolism, influence on insulin sensitivity, and anti-inflammatory properties. Moreover, the paper highlights the latest strategies to augment adiponectin levels, such as gene therapy, pharmacological interventions, dietary modifications, and lifestyle changes. It also addresses the challenges encountered in translating preclinical findings into clinical practice, primarily related to drug delivery, safety, and efficacy. Lastly, the review proposes future directions, underlining the need for large-scale human trials, novel adiponectin analogs, and personalized treatment strategies to harness adiponectin's full therapeutic potential in preventing the transition from prediabetes to diabetes.

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肥胖素在糖尿病前期的治疗潜力：策略、挑战和未来方向。

脂联素是一种源自脂肪的激素，在葡萄糖调节和脂质代谢中发挥着关键作用，循环中脂联素水平的降低与胰岛素抵抗和糖尿病前期有关。这篇综述探讨了脂肪连通素在控制糖尿病前期方面的治疗潜力，阐明了其在葡萄糖和脂质代谢中的作用、对胰岛素敏感性的影响以及抗炎特性等多个方面。此外，论文还重点介绍了提高脂肪连接蛋白水平的最新策略，如基因疗法、药物干预、饮食调整和生活方式改变。论文还探讨了在将临床前研究结果转化为临床实践过程中遇到的挑战，这些挑战主要与给药、安全性和有效性有关。最后，这篇综述提出了未来的研究方向，强调了大规模人体试验、新型脂肪连接素类似物和个性化治疗策略的必要性，以充分发挥脂肪连接素的治疗潜力，防止从糖尿病前期转变为糖尿病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567