Manifestation of Pancytopenia Associated with COVID-19 as Paroxysmal Nocturnal Hemoglobinuria (PNH) and Aplastic Anemia (AA).

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-17 DOI:10.3390/hematolrep16010005

Jeff Justin Aguilar, Vikram Dhillon, Suresh Balasubramanian

引用次数: 0

Abstract

We report two cases of pancytopenia in patients after recovering from a mild COVID-19, now presenting as paroxysmal nocturnal hemoglobinuria (PNH) and aplastic anemia. These cases illustrate a common pathway whereby a viral trigger causes the clonal expansion of a hematological disorder. Although the association of both cases with COVID-19 is temporal and COVID-19 may be an incidental diagnosis, the growing evidence related to the hematological effects of SARS-CoV-2 infection highlights the need for further investigation into the hematological consequences of COVID-19, particularly in the post-pandemic era.

查看原文本刊更多论文

与 COVID-19 有关的全血细胞减少症表现为阵发性夜间血红蛋白尿 (PNH) 和再生障碍性贫血 (AA)。

我们报告了两例从轻度 COVID-19 恢复后出现全血细胞减少的患者，他们现在表现为阵发性夜间血红蛋白尿（PNH）和再生障碍性贫血。这些病例说明了病毒引发血液病克隆扩增的常见途径。虽然这两个病例与 COVID-19 的关联是暂时的，而且 COVID-19 可能是偶然诊断，但越来越多的证据表明，SARS-CoV-2 感染对血液学的影响突出表明，有必要进一步研究 COVID-19 对血液学的影响，尤其是在大流行后的时代。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.