Caged Xanthones and Biphenyls Isolated from the Tropical Plant Garcinia lateriflora

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2024-01-22 DOI:10.1021/acs.jnatprod.3c00934

Ayano Kobayashi, Yohei Saito, Katsunori Miyake, Shuichi Fukuyoshi, David J. Newman, Barry R. O’Keefe, Kuo-Hsiung Lee and Kyoko Nakagawa-Goto*,

引用次数: 0

Abstract

Four cytotoxic heptacyclic caged-xanthones [gambogefic acids B–E (1–4)], a cytotoxic hexacyclic caged-xanthone [garcilatelic acid (5)], and four biphenyl derivatives [garcilatelibiphenyls A–D (6–9)] were newly isolated in a phytochemical study of a 50% MeOH/CH₂Cl₂ extract of Garcinia lateriflora (Clusiaceae). The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines including a vincristine-resistant line. The new caged-xanthones displayed potent activity with IC₅₀ values from 0.5 to 6.7 μM against all tested tumor cell lines.

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从热带植物红花藤中分离出的笼黄酮和联苯。

在对红花藤（藤黄科）50% MeOH/CH2Cl2 提取物进行的植物化学研究中，新分离出四种细胞毒性七环笼黄酮[gambogefic acids B-E (1-4)]、一种细胞毒性六环笼黄酮[garcilatelic acid (5)]和四种联苯衍生物[garcilatelibiphenyls A-D (6-9)]。研究人员评估了这些化合物对五种人类肿瘤细胞系（包括一种耐长春新碱的细胞系）的抗增殖活性。新的笼黄酮类化合物对所有测试的肿瘤细胞系都显示出了很强的活性，其 IC50 值从 0.5 μM 到 6.7 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.