Julie D. White, Melyssa S. Minto, Caryn Willis, Bryan C. Quach, Shizhong Han, Ran Tao, Amy Deep-Soboslay, Lea Zillich, Shaunna L. Clark, Edwin J. C. G. van den Oord, Thomas M. Hyde, R. Dayne Mayfield, Bradley T. Webb, Eric O. Johnson, Joel E. Kleinman, Laura J. Bierut, Dana B. Hancock
{"title":"Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex","authors":"Julie D. White, Melyssa S. Minto, Caryn Willis, Bryan C. Quach, Shizhong Han, Ran Tao, Amy Deep-Soboslay, Lea Zillich, Shaunna L. Clark, Edwin J. C. G. van den Oord, Thomas M. Hyde, R. Dayne Mayfield, Bradley T. Webb, Eric O. Johnson, Joel E. Kleinman, Laura J. Bierut, Dana B. Hancock","doi":"10.1101/2024.01.17.23300238","DOIUrl":null,"url":null,"abstract":"<strong>Background</strong> Alcohol use disorder (AUD) has a profound public health impact. However, understanding of the molecular mechanisms underlying the development and progression of AUD remain limited. Here, we interrogate AUD-associated DNA methylation (DNAm) changes within and across addiction-relevant brain regions: the nucleus accumbens (NAc) and dorsolateral prefrontal cortex (DLPFC).","PeriodicalId":501282,"journal":{"name":"medRxiv - Addiction Medicine","volume":"9 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Addiction Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.01.17.23300238","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background Alcohol use disorder (AUD) has a profound public health impact. However, understanding of the molecular mechanisms underlying the development and progression of AUD remain limited. Here, we interrogate AUD-associated DNA methylation (DNAm) changes within and across addiction-relevant brain regions: the nucleus accumbens (NAc) and dorsolateral prefrontal cortex (DLPFC).