Elevated Anti-Xa in the Setting of Prophylactic Unfractionated Subcutaneous Heparin Administration.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 Epub Date: 2024-01-18 DOI:10.1177/08971900241228951

Tatiana Weinstein, Diana Altshuler, Elyse Lafond, Alyson Katz

引用次数: 0

Abstract

Venous thromboembolism prophylaxis with subcutaneous unfractionated heparin or low molecular weight heparin is a common practice in hospitalized patients. Typically, prophylactic doses of these medications have poor bioavailability and thus do not reach therapeutic serum concentrations. However, in certain circumstances, heparin binding proteins may become saturated. Here we report a case series of 5 patients who had elevated anti-Xa levels while receiving prophylactic dosing of subcutaneous unfractionated heparin.

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预防性注射皮下注射肝素后抗 Xa 升高。

使用皮下注射非分数肝素或低分子量肝素预防静脉血栓栓塞症是住院患者的常见做法。通常情况下，这些药物的预防剂量生物利用度较低，因此无法达到治疗血清浓度。然而，在某些情况下，肝素结合蛋白可能会饱和。在此，我们报告了一个病例系列，其中有 5 名患者在接受皮下注射非分数肝素预防性用药期间出现抗 Xa 水平升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.