Using BCG vaccination to protect against COVID-19: when reality fails to meet expectation

IF 67.7 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2024-01-18 DOI:10.1038/s41577-024-00992-z

Laure F. Pittet, Christie C. A. Noble, Nicole L. Messina, Nigel Curtis

引用次数: 0

Abstract

While anticipating the development of a COVID-19-specific vaccine, several randomized controlled trials (RCTs) explored the potential of BCG vaccination to protect against COVID-19, based on trials demonstrating beneficial effects of BCG vaccination on unrelated infections and all-cause mortality in neonates in high-mortality geographical settings. Results are now available from 12 RCTs, which suggest that BCG vaccination is not an effective intervention against COVID-19. That the BCG–COVID-19 trials failed to meet expectation emphasizes the importance of rigorous clinical trials to validate hypotheses, even in urgent situations such as a pandemic.

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使用卡介苗预防 COVID-19：当现实与期望不符时。

在期待开发 COVID-19 特异性疫苗的同时，几项随机对照试验 (RCT) 探索了接种卡介苗预防 COVID-19 的可能性，这些试验基于卡介苗接种对高死亡率地区新生儿的非相关感染和全因死亡率的有益影响。目前已有 12 项研究性试验的结果表明，接种卡介苗并不是预防 COVID-19 的有效干预措施。卡介苗-COVID-19试验未能达到预期效果，这强调了严格的临床试验对验证假设的重要性，即使在大流行等紧急情况下也是如此。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.