Characterisation of extracellular vesicles properties and miRNAs profiles in Brown Swiss milk

IF 2.5 2区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY
Chunmei Du, Suyu Quan, Jian Ma, Fuquan Yin, Mengsi Xu, Liuxia Lin, Guangxian Zhou, Jiang Wu, Shangquan Gan
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引用次数: 0

Abstract

The conserved extracellular vesicles (EVs)-miRNAs from milk might potentially influence human gene expression, or even introduce their analogous nucleotide chains into the human food chain. This study aimed to characterise the features of Brown Swiss milk EVs and the EVs-miRNAs profile. Brown Swiss milk EVs exhibited a cup-shaped morphology, with a distribution of (2.3 ± 0.8) E + 11 particles/mL. Sequencing identified a total of 238 miRNAs, which were mainly implicated in immune response and cell signal transduction. The conservation of these milk EVs-miRNAs among species suggested they might be evolutionarily selected to regulate the growth and development of the newborns.

Abstract Image

Abstract Image

褐瑞士牛奶中细胞外囊泡特性和 miRNAs 图谱的表征
牛奶中的保守细胞外囊泡 (EVs) -miRNAs 有可能影响人类基因的表达,甚至将其类似的核苷酸链引入人类食物链。本研究旨在描述棕瑞牛奶EVs的特征以及EVs-miRNAs的概况。棕色瑞士牛奶的EVs呈杯状形态,分布为(2.3 ± 0.8)E + 11颗粒/毫升。测序共鉴定出 238 个 miRNAs,它们主要与免疫反应和细胞信号转导有关。这些牛奶EVs-miRNAs在物种间的保留表明,它们可能是进化选择出来的,用于调节新生儿的生长发育。
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来源期刊
International Journal of Dairy Technology
International Journal of Dairy Technology 工程技术-食品科技
CiteScore
7.00
自引率
4.50%
发文量
76
审稿时长
12 months
期刊介绍: The International Journal of Dairy Technology ranks highly among the leading dairy journals published worldwide, and is the flagship of the Society. As indicated in its title, the journal is international in scope. Published quarterly, International Journal of Dairy Technology contains original papers and review articles covering topics that are at the interface between fundamental dairy research and the practical technological challenges facing the modern dairy industry worldwide. Topics addressed span the full range of dairy technologies, the production of diverse dairy products across the world and the development of dairy ingredients for food applications.
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