Cyanoacrylate Adhesives Used for Topical Hemostasis A Systematic Review.

IF 0.8 Q4 SURGERY

Chirurgia Pub Date : 2023-12-01 DOI:10.21614/chirurgia.2023.v.118.i.6.p.596

Alexandru Ilie-Ene, Victor Eşanu, Vlad Făgărăşan, Victor Petru Toşa, George-Călin Dindelegan

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引用次数: 0

Abstract

Introduction: In this systematic review the topical hemostatic properties of Cyanoacrylate Adhesives (CA) have been studied. Material and Method: Four major scientific databases (Embase, Scopus, PubMed, and Web of Science) were inquired, retrieving reviews and meta-analysis studies, clinical trials, experimental studies, and case reports that presented data regarding topical hemostasis and CA. English written articles, published in the last 10 years were collected. The last search was performed on the 1st of August 2023. Risk of bias in the included studies was assessed using study-design specific, evidence-based tools. Results: A summary focused on relevant information of all included studies was drafted and the results of the studies have been synthetized and compared. A total of 42 studies have been included in the review (14 reviews and meta-analysis, 11 clinical trials, 9 experimental studies and 8 case reports). CA exhibited important topical hemostatic capabilities, comparable with other performant hemostatic materials. Although most included studies concluded that CA were potent topical hemostatic agents, the high level of heterogeneity among the studies prevented us from performing a meta-analysis. Conclusion: The results of this review show that CA-based compounds represent an important line of research towards the perfect hemostatic material.

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用于局部止血的氰基丙烯酸酯粘合剂系统综述

简介：本系统综述研究了氰基丙烯酸酯粘合剂（CA）的局部止血特性。材料与方法：查询了四个主要科学数据库（Embase、Scopus、PubMed 和 Web of Science），检索了综述和荟萃分析研究、临床试验、实验研究以及病例报告，其中提供了有关局部止血和 CA 的数据。收集了过去 10 年中发表的英文文章。最后一次检索于 2023 年 8 月 1 日进行。使用研究设计专用的循证工具评估了纳入研究的偏倚风险。结果起草了一份以所有纳入研究的相关信息为重点的摘要，并对研究结果进行了综合和比较。共有 42 项研究被纳入综述（14 项综述和荟萃分析、11 项临床试验、9 项实验研究和 8 项病例报告）。CA 具有重要的局部止血功能，可与其他高效止血材料相媲美。虽然大多数纳入的研究都认为 CA 是强效的局部止血剂，但研究之间的高度异质性使我们无法进行荟萃分析。结论本综述的结果表明，基于 CA 的化合物是研究完美止血材料的一个重要方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chirurgia Medicine-Surgery

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Chirurgia is a bimonthly journal. In Chirurgia, original papers in the area of general surgery which neither appeared, nor were sent for publication in other periodicals, can be published. You can send original articles, new surgical techniques, or comprehensive general reports on surgical topics, clinical case presentations and, depending on publication space, - reviews of some articles of general interest to surgeons from other publications. Chirurgia is also a place for sharing information about the activity of various branches of the Romanian Society of Surgery, information on Congresses and Symposiums organized by the Romanian Society of Surgery and participation notes in other scientific meetings. Letters to the editor: Letters commenting on papers published in Chirurgia are welcomed. They should contain substantive ideas and commentaries supported by appropriate data, and should not exceed 2 pages. Please submit these letters to the editor through our online system.