Pathophysiology of Acute Myeloid Leukemia.

IF 1.1 4区医学 Q3 HEMATOLOGY

Acta Haematologica Pub Date : 2024-01-01 Epub Date: 2024-02-16 DOI:10.1159/000536152

Franziska Wachter, Yana Pikman

引用次数: 0

Abstract

Background: Acute myeloid leukemia (AML) is a biologically heterogenous disease arising in clonally proliferating hematopoietic stem cells. Sequential acquisition of mutations leads to expanded proliferation of clonal myeloid progenitors and failure of differentiation, leading to fulminant AML.

Summary: Here, we review the pathophysiology of AML with a focus on factors predisposing to AML development, including prior chemo- and radiation therapy, environmental factors, and germline predisposition.

Key message: Increasing genomic characterization of AML and insight into mechanisms of its development will be critical to improvement in AML prognostication and therapy.

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急性髓性白血病（AML）的病理生理学。

急性髓性白血病（AML）是一种生物异质性疾病，产生于克隆性增殖的造血干细胞。突变的连续获得导致克隆髓系祖细胞的增殖扩大和分化失败，从而导致暴发性急性髓细胞白血病。在此，我们回顾了急性髓细胞性白血病的病理生理学，重点探讨了导致急性髓细胞性白血病的易感因素，包括之前的化疗和放疗、环境因素和种系易感性。增加急性髓细胞性白血病的基因组特征并深入了解其发病机制对改善急性髓细胞性白血病的预后和治疗至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Haematologica 医学-血液学

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Acta Haematologica'' is a well-established and internationally recognized clinically-oriented journal featuring balanced, wide-ranging coverage of current hematology research. A wealth of information on such problems as anemia, leukemia, lymphoma, multiple myeloma, hereditary disorders, blood coagulation, growth factors, hematopoiesis and differentiation is contained in first-rate basic and clinical papers some of which are accompanied by editorial comments by eminent experts. These are supplemented by short state-of-the-art communications, reviews and correspondence as well as occasional special issues devoted to ‘hot topics’ in hematology. These will keep the practicing hematologist well informed of the new developments in the field.