Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-04-01 DOI:10.1016/j.tibs.2024.01.001

Francisco J. Fernández , M. Cristina Vega

引用次数: 0

Abstract

Recent advances in cryo-electron microscopy (Cryo-EM) have revolutionized our understanding of the complement C5a/C3a receptors that are crucial in inflammation. A recent report by Yadav et al. has elucidated the activation, ligand binding, selectivity, and signaling bias of these receptors, thereby enhancing structure-guided drug discovery. This paves the way for more effective anti-inflammatory therapies that target these receptors with unprecedented precision.

查看原文本刊更多论文

解码苊毒素：揭示补体受体激活和信号传导的分子机制

低温电子显微镜（Cryo-EM）的最新进展彻底改变了我们对炎症中至关重要的补体 C5a/C3a 受体的认识。Yadav 等人最近的一份报告阐明了这些受体的激活、配体结合、选择性和信号传导偏差，从而提高了以结构为导向的药物发现能力。这为以这些受体为靶点的更有效、更精准的抗炎疗法铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.