Recent Advancements in the Therapeutic Development for Marburg Virus: Updates on Clinical Trials

IF 3.1 4区医学 Q2 INFECTIOUS DISEASES

Current Infectious Disease Reports Pub Date : 2024-01-15 DOI:10.1007/s11908-023-00828-2

Garima Sharma, Ashish Ranjan Sharma, Jin-Chul Kim

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Abstract

Purpose of Review

We aim to provide valuable insights into the current state of therapeutic development for the deadly Marburg virus and guide researchers and clinicians to study the emerging therapies and shape future directions against this deadly virus.

Recent Findings

We find considerable progress in understanding the molecular biology and pathogenesis of the Marburg virus, leading to the identification of small-molecule antivirals and host-targeted approaches, including RNA polymerase inhibitors, viral entry inhibitors, and RNA interference therapies. However, there are very few ongoing clinical trials on the therapy/vaccine development against Marburg virus. Some of the potential studied candidates are chimpanzee adenovirus type 3, modified vaccinia Ankara, Marburg DNA plasmid vaccine, antisense phosphorodiamidate morpholino oligomers, and galidesivir. Yet, there are no approved vaccines or drugs against Marburg virus due to the viral genetic variability.

Summary

Extensive efforts and global awareness in the scientific society are requisite to develop preventive and therapeutic measures focusing on combinatorial formulations against Marburg virus.

Abstract Image

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马尔堡病毒治疗开发的最新进展：临床试验的最新进展

最近的研究结果我们发现，在了解马尔堡病毒的分子生物学和发病机制方面取得了很大进展，从而确定了小分子抗病毒药物和宿主靶向方法，包括 RNA 聚合酶抑制剂、病毒进入抑制剂和 RNA 干扰疗法。然而，目前正在进行的针对马尔堡病毒的疗法/疫苗开发临床试验非常少。一些潜在的候选研究药物包括黑猩猩腺病毒 3 型、改良安卡拉疫苗、马尔堡 DNA 质粒疫苗、反义磷酰吗啉寡聚体和加列地韦。由于病毒基因的变异性，目前还没有针对马尔堡病毒的疫苗或药物获得批准。小结科学界需要做出广泛的努力并提高全球意识，以开发针对马尔堡病毒的组合制剂为重点的预防和治疗措施。

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来源期刊

Current Infectious Disease Reports INFECTIOUS DISEASES-

CiteScore

6.70

自引率

0.00%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of infectious disease. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as HIV/AIDS, sexually transmitted diseases, tropical and travel medicine, and urinary tract infections. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists.